Table 2 Main demographic and clinical features of T-ALL patients according to type and classification of NOTCH1 mutations
From: Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia
Variables | Point Mutationsa (%) | Complex Mutations n (%) | p value | Missense n (%) | Nonsense n (%) | p value |
|---|---|---|---|---|---|---|
Age (Years) | ||||||
< 10 | 14 (42.4) | 14 (51.9) | 0.466 | 21 (45.7) | 7 (50.0) | 0.775 |
10-18 | 19 (57.6) | 13 (48.1) | 25 (54.3) | 7 (50.0) | ||
Gender | ||||||
Male | 26 (78.8) | 20 (74.1) | 0.668 | 34 (73.9) | 12 (85.7) | 0.361 |
Female | 7 (21.2) | 7 (25.9) | 12 (26.1) | 2 (14.3) | ||
WBC (x109/L) | ||||||
<50 | 20 (60.6) | 9 (33.3) | 0.035 | 23 (50.0) | 6 (42.9) | 0.640 |
≥50 | 13 (39.4) | 18 (66.7) | 23 (50.0) | 8 (57.1) | ||
Skin colour | ||||||
White | 8 (24.2) | 13 (48.1) | 0.053 | 15 (32.6) | 6 (42.9) | 0.481 |
Non-white | 25 (75.8) | 14 (51.9) | 31 (67.4) | 8 (57.1) | ||
T-ALL subtypesb | ||||||
T-I | 4 (12.9) | 5 (18.5) | 0.825 | 8 (17.8) | 1 (7.6) | 0.589 |
T-II | 4 (12.9) | 5 (18.5) | 6 (13.3) | 3 (23.1) | ||
T-III | 10 (32.3) | 8 (29.6) | 15 (33.3) | 3 (23.1) | ||
T-IV | 13 (41.9) | 9 (33.3) | 16 (35.6) | 6 (46.2) | ||
CD10 statusc | ||||||
Positive | 11 (39.3) | 5 (20.0) | 0.127 | 15 (37.5) | 1 (7.7) | 0.042 |
Negative | 17 (60.7) | 20 (80.0) | 25 (62.5) | 12 (92.3) | ||
NOTCH1 mutated domain | ||||||
HD | 28 (84.8) | 14 (51.9) | 0.014 | 38 (82.6) | 4 (28.6) | <0.0001 |
PEST/TAD | 4 (12.1) | 7 (25.9) | 4 (8.7) | 7 (50.0) | ||
Both domains | 1 (3.0) | 6 (22.2) | 4 (8.7) | 3 (21.4) | ||
FBXW7statusd | ||||||
Mutated | 6 (20.0) | 7 (29.2) | 0.434 | 11 (27.5) | 2 (14.3) | 0.320 |
WT | 24 (80.0) | 17 (70.8) | 29 (72.5) | 12 (85.7) | ||
Total | 33 (100) | 27 (100) | 46 (100) | 14 (100) |