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Table 3 Multivariate analysis (Cox proportional hazard model)

From: Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases

KRAS Wild-type patients (n = 66)     
Factor Cut-off No. of pts Median times (months) Univariate analysis Multivariate analysis
     HR (95%CI) p-valule HR(95%CI) p-value
EREG Low 34 74.1 1.00 0.021* 1.00 0.006*
  High 30 42.1 2.80   3.73  
     (1.17-7.03)   (1.46-10.10)  
pN Negative 15 not reached 1.00 0.022* 1.00 0.014*
  Positive 49 47.6 3.28   3.66  
     (1.17-11.74)   (1.28-13.34)  
Depth T1,2 8 not reached 1.00 0.398 1.00 0.111
  T3,4 56 56.6 1.78   2.98  
     (0.52-11.16)   (0.80-19.41)  
KRAS mutant patients (n = 43)     
Factor Cut-off No. of pts Median times (months) Univariate analysis Multivariate analysis
     HR (95%CI) p-valule HR(95%CI) p-value
EREG Low 22 37.1 1.00 0.048* 1.00 0.090
  High 21 58.1 0.37   0.42  
     (0.13-0.99)   (0.14-1.14)  
pN Negative 17 not reached 1.00 0.182 1.00 0.383
  Positive 26 41.4 1.98   1.58  
     (0.73-6.25)   (0.58-5.03)  
Depth T1,2 6 not reached 1.00 0.178 1.00 0.301
  T3,4 37 37.1 3.21   2.55  
     (0.65-58.11)   (0.51-46.40)