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Table 3 Multivariate analysis (Cox proportional hazard model)

From: Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases

KRAS Wild-type patients (n = 66)

    

Factor

Cut-off

No. of pts

Median times (months)

Univariate analysis

Multivariate analysis

    

HR (95%CI)

p-valule

HR(95%CI)

p-value

EREG

Low

34

74.1

1.00

0.021*

1.00

0.006*

 

High

30

42.1

2.80

 

3.73

 
    

(1.17-7.03)

 

(1.46-10.10)

 

pN

Negative

15

not reached

1.00

0.022*

1.00

0.014*

 

Positive

49

47.6

3.28

 

3.66

 
    

(1.17-11.74)

 

(1.28-13.34)

 

Depth

T1,2

8

not reached

1.00

0.398

1.00

0.111

 

T3,4

56

56.6

1.78

 

2.98

 
    

(0.52-11.16)

 

(0.80-19.41)

 

KRAS mutant patients (n = 43)

    

Factor

Cut-off

No. of pts

Median times (months)

Univariate analysis

Multivariate analysis

    

HR (95%CI)

p-valule

HR(95%CI)

p-value

EREG

Low

22

37.1

1.00

0.048*

1.00

0.090

 

High

21

58.1

0.37

 

0.42

 
    

(0.13-0.99)

 

(0.14-1.14)

 

pN

Negative

17

not reached

1.00

0.182

1.00

0.383

 

Positive

26

41.4

1.98

 

1.58

 
    

(0.73-6.25)

 

(0.58-5.03)

 

Depth

T1,2

6

not reached

1.00

0.178

1.00

0.301

 

T3,4

37

37.1

3.21

 

2.55

 
    

(0.65-58.11)

 

(0.51-46.40)

 
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BMC Cancer

ISSN: 1471-2407

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