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Table 4 Reports of miR-200 in ovarian cancer

From: Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer

miRNA Findings Reference
200a/b/c High expression in ovarian cancer samples [7, 8, 10]
  High expression correlated with decreased progression-free survival [8]
  Decreased in tumors with high β-tubulin III levels [33]
200a Increased in 43% of primary ovarian carcinomas, associated with high-grade and late-stage tumors [9]
  High expression correlated with recurrence free survival and, or, overall survival [34, 35]
  Increased tumour growth, targets p38α and modulates oxidative stress signature [34]
  Sensitized tumors to paclitaxel [34]
200c Targeted TUBB3 for degradation leading to increased paclitaxel sensitivity [36]
  Low levels associated with incomplete response to paclitaxel–carboplatin chemotherapy and recurrence [33]
  Decreased adhesion to basement membrane complex [36]
  Repressed ZEB1, decreased migration and invasion in HEY cells [36]