Table 2 Genes down regulated in SK-NEP-1 cells treated with YM155 compared with DMSO control group

1

HIPK2

Homeodomain interacting protein kinase 2

31.640

11.619

0.367

0.0353

2

CD27

CD27 molecule

1.462

0.538

0.368

0.0353

3

PCBP4

Poly(rC) binding protein 4

9.419

3.481

0.370

0.0334

4

PAK7

P21 protein (Cdc42/Rac)-activated kinase 7

0.120

0.044

0.370

0.0334

5

PPP1R13B

Protein phosphatase 1, regulatory subunit 13B

75.280

27.926

0.371

0.0322

6

TP73

Tumor protein p73

9.738

3.619

0.372

0.0321

7

RASA1

RAS p21 protein activator 1

138.406

49.465

0.357

0.0315

8

CRYAA

Crystallin, alpha A

0.210

0.079

0.375

0.0272

9

TIAF1

TGFB1-induced anti-apoptotic factor 1

243.057

91.076

0.375

0.0242

10

CARD14

Caspase recruitment domain family, member 14

37.791

13.412

0.355

0.0241

11

NOD1

Nucleotide-binding domain containing 1

163.081

61.858

0.379

0.0214

12

TNFRSF1B

Tumor necrosis factor receptor superfamily 1B

45.110

17.323

0.384

0.0174

13

HIP1

Huntingtin interacting protein 1

14.568

4.941

0.339

0.0174

14

UTP11L

UTP11-like, U3 small nucleolar ribonucleoprotein

267.624

104.245

0.390

0.0118

15

SPP1

Secreted phosphoprotein 1

2.389

0.801

0.335

0.0107

16

NME5

NME/NM23 family member 5

0.217

0.073

0.335

0.0092

17

MYO18A

Myosin XVIIIA

164.894

54.821

0.332

0.0087

18

PPP2R1B

Protein phosphatase 2, regulatory subunit A

9.768

3.887

0.398

0.0033

19

BAG1

BCL2-associated athanogene

70.273

28.001

0.398

0.0033

20

DAPK2

Death-associated protein kinase 2

1.549

0.509

0.329

0.0023

21

TNFSF10

Tumor necrosis factor (ligand) superfamily 10

2.596

0.844

0.325

0.0022

22

TNFRSF25

Tumor necrosis factor receptor superfamily 25

10.685

4.340

0.406

0.0022

23

FOXL2

Forkhead box L2

11.954

4.886

0.409

0.0021

24

CASP10

Caspase 10, apoptosis-related cysteine peptidase

13.465

4.252

0.316

0.0021

25

CARD8

Caspase recruitment domain family, member 8

3.835

1.209

0.315

0.0020

26

ALOX12

Arachidonate 12-lipoxygenase

9.725

3.039

0.312

0.0020

27

OPA1

Optic atrophy 1 (autosomal dominant)

172.500

71.720

0.416

0.0020

28

ERN2

Endoplasmic reticulum to nucleus signaling 2

2.851

1.187

0.416

0.0020

29

STK17A

Serine/threonine kinase 17a

111.835

46.583

0.417

0.0020

30

CARD9

Caspase recruitment domain family, member 9

5.195

1.578

0.304

0.0020

31

GRM4

Glutamate receptor, metabotropic 4

0.958

0.408

0.426

0.0020

32

SON

SON DNA binding protein

547.934

234.409

0.428

0.0019

33

PLAGL2

Pleiomorphic adenoma gene-like 2

69.972

30.027

0.429

0.0019

34

BIRC5

Baculoviral IAP repeat containing 5

59.315

25.502

0.430

0.0019

35

FADD

Fas (TNFRSF6)-associated via death domain

323.082

93.703

0.290

0.0019

36

NAIP

NLR family, apoptosis inhibitory protein

44.019

12.731

0.289

0.0008

37

BCL2

B-cell CLL/lymphoma 2

6.950

3.020

0.435

0.0008

38

ZNF443

Zinc finger protein 443

8.149

3.583

0.440

0.0003

39

CASP8AP2

Caspase 8 associated protein 2

43.673

19.445

0.445

0.0003

40

CUL5

Cullin 5

134.969

60.117

0.445

0.0002

41

DAPK1

Death-associated protein kinase 1

15.806

4.237

0.268

<0.0001

42

NKX3-2

NK3 homeobox 2

0.830

0.371

0.447

<0.0001

43

SEMA4D

Itransmembrane domain semaphoring 4D

9.709

2.589

0.267

<0.0001

44

SST

Somatostatin

0.694

0.179

0.258

<0.0001

45

ALOX15B

Arachidonate 15-lipoxygenase, type B

0.263

0.063

0.242

<0.0001

46

NOTCH2

Notch 2

930.886

223.933

0.241

<0.0001

47

NLRC4

NLR family, CARD domain containing 4

20.624

4.653

0.226

<0.0001

48

PRKCA

Protein kinase C, alpha

30.560

6.439

0.211

<0.0001

49

APOE

Apolipoprotein E

1.075

0.210

0.195

<0.0001

50

NTF3

Neurotrophin 3

0.295

0.044

0.150

<0.0001

51

CARD17

Caspase recruitment domain family, member 17

0.363

0.047

0.131

<0.0001

52

MAPK8IP2

Mitogen kinase 8 interacting protein 2

0.432

0.049

0.114

<0.0001

53

F2

coagulation factor II

3.794

0.104

0.027

<0.0001

54

CUL3

cullin 3

1.228

0.059

0.048

<0.0001