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Figure 2 | BMC Cancer

Figure 2

From: Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1)

Figure 2

The chimeric antigen receptor F19 is a fusion protein which consists of four functional domains. The scFv F19 serves as binding domain and binds to FAP. The IgG Fc-domain functions as a spacer (hinge); the CD28 signalling domain leads to co-stimulation and the CD3ζ signalling domain activates the T cell if the receptor is cross-linked via antigen binding. The CAR will be expressed in CD8 positive T cells with unknown endogenous specificity.

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