Table 2 Univariate log-rank analyses for disease-specific, metastasis-free, and urinary bladder recurrence-free survival

Gender

Male

158

28

0.8286

32

0.7904

43

0.0369*

Female

182

33

38

36

Age (years)

<65

138

26

0.9943

30

0.8470

34

0.5107

≥65

202

35

40

45

Tumor side

Right

177

34

0.7366

38

0.3074

44

0.6047

Left

154

26

32

32

Bilateral

9

1

0

3

Tumor location

Renal pelvis

141

24

0.0079*

31

0.0659

33

0.1723

Ureter

150

22

25

32

Renal pelvis and ureter

49

15

14

14

Multifocality

Single

273

48

0.0026*

52

0.0127*

64

0.1861

Multifocal

62

18

18

15

Primary tumor (T)

Ta ~ T1

181

11

<0.0001*

19

<0.0001*

43

0.2688

T2 ~ T4

159

50

51

36

Nodal metastasis

Negative (N0)

312

42

<0.0001*

55

<0.0001*

73

0.1422

Positive (N1 ~ N2)

28

19

15

6

Histological grade

Low grade

56

4

0.0215*

3

0.0027*

14

0.0056*

High grade

284

57

67

65

Pattern of invasion

Non-invasive/nodular

200

19

<0.0001*

27

<0.0001*

50

0.5398

Trabecular

58

12

13

14

Infiltrative

82

30

30

15

Vascular invasion

Absent

234

24

<0.0001*

26

<0.0001*

55

0.1770

Present

106

37

44

24

Perineurial invasion

Absent

321

50

<0.0001*

61

<0.0001*

75

0.2169

Present

19

11

9

4

Mitotic rate (per 10 high power fields)

<10

173

27

0.1607

30

0.0823

43

0.9031

≥10

167

34

40

36

Adjuvant chemotherapy

Not performed

311

54

0.4084

61

0.2151

70

0.2740

Performed

29

7

9

9

HuR cytoplasmic expression

Low

170

13

<0.0001*

19

<0.0001*

33

0.0370*

High

170

48

51

46

Cyclin A expression

Low

170

19

0.0035*

22

0.0015*

36

0.3784

High

170

42

48

43