Parameter |  | No. of cases | HuR Cyto. Exp.†| pvalue | Cyclin A Exp. | pvalue | ||
---|---|---|---|---|---|---|---|---|
Low | High | Low | High | |||||
Gender | Male | 182 | 93 | 89 | 0.664 | 85 | 95 | 0.384 |
Female | 158 | 77 | 81 | Â | 83 | 75 | Â | |
Age (years) | <65 | 138 | 72 | 66 | 0.508 | 75 | 63 | 0.185 |
≥65 | 202 | 98 | 104 |  | 95 | 107 |  | |
Tumor side | Right | 177 | 96 | 81 | 0.201 | 89 | 88 | 0.931 |
Left | 154 | 71 | 83 | Â | 76 | 78 | Â | |
Bilateral | 9 | 3 | 6 | Â | 5 | 4 | Â | |
Tumor location | Renal pelvis | 141 | 76 | 65 | 0.374 | 66 | 75 | 0.607 |
Ureter | 150 | 73 | 77 | Â | 78 | 72 | Â | |
Renal pelvis and ureter | 49 | 21 | 28 | Â | 26 | 23 | Â | |
Multifocality | Single | 278 | 143 | 135 | 0.261 | 140 | 138 | 0.779 |
Multifocal | 62 | 27 | 35 | Â | 30 | 32 | Â | |
Primary tumor (T) | Ta ~ T1 | 181 | 109 | 72 | <0.001* | 104 | 77 | 0.003* |
T2 ~ T4 | 159 | 61 | 98 |  | 66 | 93 |  | |
Nodal metastasis | Negative (N0) | 312 | 166 | 146 | <0.001* | 159 | 153 | 0.237 |
Positive (N1 ~ N2) | 28 | 4 | 24 |  | 11 | 17 |  | |
Histological grade | Low grade | 56 | 37 | 19 | 0.008* | 39 | 17 | 0.001* |
High grade | 284 | 133 | 151 | Â | 131 | 151 | Â | |
Pattern of invasion | Non-invasive/Nodular | 200 | 112 | 88 | 0.030* | 108 | 92 | 0.191 |
Trabecular | 58 | 24 | 34 | Â | 27 | 31 | Â | |
Infiltrative | 82 | 34 | 48 | Â | 35 | 47 | Â | |
Vascular invasion | Absent | 234 | 126 | 108 | 0.035* | 124 | 110 | 0.101 |
Present | 106 | 44 | 62 | Â | 46 | 60 | Â | |
Perineurial invasion | Absent | 321 | 166 | 155 | 0.009* | 162 | 159 | 0.479 |
Present | 19 | 4 | 15 | Â | 8 | 11 | Â | |
Mitotic rate (per 10 high power fields) | <10 | 173 | 89 | 84 | 0.588 | 103 | 70 | <0.001* |
≥10 | 167 | 81 | 86 |  | 67 | 100 |  | |
Cyclin A expression | Low | 164 | 95 | 69 | 0.005* | - | - | - |
High | 176 | 75 | 101 | Â | - | - | Â |