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Table 4 Numbers of pathways displaying significant tumor-associated dysregulation in RS analysis and GSEA of the N vs SPL, N vs LPL, and N vs. CRC data sets

From: Molecular pathways undergoing dramatic transcriptomic changes during tumor development in the human colon

Differential regulation in tumors RS GSEA Overlap
No. pathways up-regulated in SPLs 23 75 21 (91%)*
No. pathways down-regulated in SPLs 41 121 37 (90%)*
No. pathways up-regulated in LPLs 21 75 20 (95%)*
No. pathways down-regulated in LPLs 29 109 26 (90%)*
No. pathways up-regulated in CRCs 33 52 16 (49%)**
No. pathways down-regulated in CRCs 25 42 21 (84%)*
  1. No. of pathways found dysregulated by RS and GSEA with p-values < 0.05.
  2. ‡ No. (%) of pathways identified as dysregulated in RS analysis that were found to be similarly dysregulated in GSEA; asterisks indicate p-values computed by Fisher’s exact test: *p=0; **p=1.1x10.-12.