Molecular pathways undergoing dramatic transcriptomic changes during tumor development in the human colon

BMC Cancer

Table 4 Numbers of pathways displaying significant tumor-associated dysregulation in RS analysis and GSEA of the N vs SPL, N vs LPL, and N vs. CRC data sets

Differential regulation in tumors^†	RS	GSEA	Overlap^‡
No. pathways up-regulated in SPLs	23	75	21 (91%)*
No. pathways down-regulated in SPLs	41	121	37 (90%)*
No. pathways up-regulated in LPLs	21	75	20 (95%)*
No. pathways down-regulated in LPLs	29	109	26 (90%)*
No. pathways up-regulated in CRCs	33	52	16 (49%)**
No. pathways down-regulated in CRCs	25	42	21 (84%)*

^† No. of pathways found dysregulated by RS and GSEA with p-values < 0.05.
‡ No. (%) of pathways identified as dysregulated in RS analysis that were found to be similarly dysregulated in GSEA; asterisks indicate p-values computed by Fisher’s exact test: *p=0; **p=1.1x10.^-12.

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