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Table 4 Patient self -evaluation of nausea and vomiting during the 1 st CT cycle (ITT population)

From: Can treatment with Cocculine improve the control of chemotherapy-induced emesis in early breast cancer patients? A randomized, multi-centered, double-blind, placebo-controlled Phase III trial

  Placebo n = 217 Cocculine n = 214 All patients n = 431 p
Nausea frequency     0.59†
missing data 16 19 35  
number of patients evaluable 201 195 396  
Number of patients with at least 1 episode of nausea, n (%) 164 (81.6) 155 (79.5) 319 (80.6)  
Nausea severity 0.61*
missing data 16 19 35  
number of patients evalubale 201 195 396  
Median (min-max) 0.56 (0–8.5) 0.58 (0–8.3) 0.56 (0–8.5)  
Vomiting frequency     0.56†
missing data 31 19 50  
number of patients evaluable 186 170 356  
Number of patients with at least 1 episode of vomiting, n (%) 51 (27.4) 42 (24.7) 93 (26.1)  
Vomiting severity
missing data 22 25 47 0.44*
number of patients evaluable 195 189 384  
Median (min-max) 0.00 (0–7.60) 0.00 (0–5.0) 0.00 (0–7.60)  
  1. *: Mann–Whitney U test †: Person’s chi-square test.