Figure 5

SNCG promotes tumorigenesis of androgen-dependent prostate cancer cells. (A) Tumorigenesis presented in siSNCG-166 group (n = 8) and NC group (n = 7, one mouse was sacrificed at 4 weeks after injection due to poor health) after subcutaneous injection of the cells. (B) Top: Tumor volume was observed twice weekly in the siSNCG-166 group compared to that in the NC group. Bottom: The mean tumor weight in the siSNCG-166 group was less than that in the NC group. (C): The mean mouse weight was measured twice weekly. No significant difference was observed between the siSNCG-166-LNCaP group and the NC-LNCaP group. (D) Mice were castrated before the indicated cells were injected. The tumor-bearing mice showed in RFP-SNCG-LNCaP group (n = 8) and RFP-LNCaP group (n = 8). (E) Top: Tumor volumes were observed twice weekly in RFP-SNCG-LNCaP group compared to RFP-LNCaP group. Bottom: The mean tumor weight showed in RFP-LNCaP group and RFP-SNCG-LNCaP group. (F): The mean mouse weight was measured twice weekly. No significant difference was observed between RFP-SNCG-LNCaP group and RFP-LNCaP group.