“Iron-saturated” bovine lactoferrin improves the chemotherapeutic effects of tamoxifen in the treatment of basal-like breast cancer in mice

Table 2 Body, tumor, organ and tissue weights ¹

	Control diet	Control diet + TAM	Lf diet	Lf diet + TAM
	(n = 6)	(n = 6)	(n = 6)	(n = 6)
Body weight (g)	16.9 ± 1.1	13.9 ± 0.4²	18.1 ± 1.1	15.0 ± 0.5^2,3,4
Carcass body weight (g)⁵	16.4 ± 1.3	13.6 ± 0.4²	18.0 ± 1.2²	14.8 ± 0.5^2,3,4
Tumor (mg)⁶	309.4 ± 32.9	216.3 ± 26.7²	194.7 ± 19.8²	146.2 ± 17.3^2,3,4
Liver (mg)⁷	1262.5 ± 44.1	1215.7 ± 109.5	1318.2 ± 40.8	1285.2 ± 86.9
Lung (mg)⁸	389.2 ± 37.1	297.2 ± 19.4²	309.3 ± 27.9²	281.3 ± 22.2²
Gastrocnemius muscle (mg)	91.8 ± 6.7	77.9 ± 8.2	99.6 ± 4.2	88.4 ± 5.0^2,3,4
Ovarian adipose tissue (mg)	26.1 ± 2.5	22.5 ± 1.7²	28.1 ± 1.3	25.0 ± 1.8³

¹Tumors, lungs, livers, small intestines, gastrocnemius muscles and ovarian adipose tissues of mice in the prevention study were excised at day 43 and weighed. Data are expressed as means ± SD. Statistical significance was determined by one way ANOVA followed by Dunnett’s test. ² P < 0.05 versus the mice fed the control diet; ³ P < 0.05 versus the mice fed the control diet and treated with TAM; ⁴ P < 0.05 versus the mice fed Lf diet. ⁵Calculated according to the formula: body weight – tumor weight. ⁶Tumor refers to primary tumor. ⁷Liver weight includes metastatic tumors. ⁸Lung weight includes metastatic tumors. TAM, tamoxifen.

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