Table 3 Sensitivity analyses

5-year follow-up prior to index date

main analysis: maximum numbers of participants in different years of follow-up

2588

18872

9435

69896

0.51

(0.29, 0.90)

0.021

using the same 5-year follow-up group for 3- year and 1-year analyses

2588

18872

9435

69896

0.51

(0.29, 0.90)

0.021

participants without any occurance of myocardial infarction or congestive heart failure

2048

17238

7584

64687

0.57

(0.30, 1.08)

0.085

patients without any occurance of peptic ulcer disease

1112

12374

4597

52859

0.61

(0.19, 1.97)

0.412

patients with any occurance of peptic ulcer disease

1476

6498

4838

17037

0.31

(0.08, 1.19)

0.089

patients without any occurance of colon or rectal polyps

2520

18447

9432

69895

0.55

(0.30, 1.98)

0.044

3-year follow-up prior to index date

main analysis: maximum numbers of participants in different years of follow-up

2393

25117

8293

90607

0.58

(0.39, 1.86)

0.007

using the same 5-year follow-up group for 3- year analysis

2376

19084

8489

70842

0.60

(0.40, 0.89)

0.011

participants without any occurance of myocardial infarction or congestive heart failure

1990

23458

7001

85573

0.61

(0.39, 0.94)

0.026

patients without any occurance of peptic ulcer disease

1190

17857

4737

74165

0.71

(0.37, 1.36)

0.304

patients with any occurance of peptic ulcer disease

1203

7260

3556

16442

0.49

(0.20, 1.20)

0.117

patients without any occurance of colon or rectal polyps

2316

18671

8488

70841

0.61

(0.40, 0.91)

0.016

1-year follow-up prior to index date

main analysis: maximum numbers of participants in different years of follow-up

1264

31959

4153

121708

0.60

(0.46, 0.80)

<.001

using the same 5-year follow-up group for 3-year and 1-year analyses

1247

20213

4380

74951

0.61

(0.46, 0.81)

0.001

participants without any occurance of myocardial infarction or congestive heart failure

1139

33696

3807

118187

0.59

(0.43, 0.79)

0.001

patients without any occurance of peptic ulcer disease

765

28501

2951

111326

0.79

(0.54, 1.15)

0.227

patients with any occurance of peptic ulcer disease

499

3458

1202

10382

0.56

(0.17, 1.85)

0.340

patients without any occurance of colon or rectal polyps

1216

19797

4379

74951

0.61

(0.46, 0.81)

0.001

6-month follow-up prior to index date

main analysis: maximum numbers of participants in different years of follow-up

822

35401

2619

123242

0.72

(0.56, 0.93)

0.012

using the same 5-year follow-up group for 3- year and 1-year analyses

806

20654

2747

76584

0.72

(0.56, 0.93)

0.013

participants without any occurance of myocardial infarction or congestive heart failure

744

34091

2411

119583

0.70

(0.53, 0.91)

0.009

patients without any occurance of peptic ulcer disease

491

28775

1855

112422

0.95

(0.68, 1.33)

0.777

patients with any occurance of peptic ulcer disease

331

6626

764

10820

0.67

(0.24, 1.88)

0.443

patients without any occurance of colon or rectal polyps

786

20227

2747

76583

0.71

(0.55, 0.92)

0.009

3-month follow-up prior to index date

main analysis: maximum numbers of participants in different years of follow-up

533

35690

1652

124209

0.80

(0.64, 1.01)

0.056

using the same 5-year follow-up group for 3-year and 1-year analyses

521

20939

1721

77610

0.80

(0.64, 1.01)

0.057

participants without any occurance of myocardial infarction or congestive heart failure

480

34355

1502

120492

0.78

(0.61, 0.98)

0.036

patients with any occurance of peptic ulcer disease

209

6748

511

11073

0.76

(0.31, 1.85)

0.550

patients without any occurance of colon or rectal polyps

507

20506

1721

77609

0.79

(0.63, 0.99)

0.038