Skip to main content

Table 2 The association of WHO grade to C4d positive tumor area, C4d positive endothelium, and to the fraction of C4d positive endothelium

From: Complement activation in astrocytomas: deposition of C4d and patient outcome

C4d EXT Mean(%) Std.(%) Median(%) p-value
Grade I 18.4 22.5 8.2 0.041*
Grade II 2.1 8.7 0.0  
Grade III 0.7 0.9 0.4  
Grade IV 8.2 17.3 0.8 0.016**
C4d END     
Grade I 0.1 0.1 0.0 n.s.*
Grade II 0.1 0.2 0.0  
Grade III 0.3 0.5 0.0  
Grade IV 0.3 0.6 0.0 n.s.**
C4d/CD34     
Grade I 4.8 12.3 0.0 n.s.*
Grade II 3.0 7.5 0.0  
Grade III 12.1 19.1 0.0  
Grade IV 20.3 71.3 0.0 n.s.**
  1. C4d EXT = C4d positive tumor area fraction, C4d END = C4d positive endothelial area fraction, C4d / CD34 = the proportion of C4d positive endothelial area fraction of the CD34 positive endothelium. p-value; * = Mann–Whitney U-test between pilocytic (grade I) and diffusely infiltrating (grades II-IV) astrocytomas; ** = Kruskal-Wallis test between different grades of diffusely infiltrating (grade II-IV) astrocytomas.