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Table 3 Progression-free survival and overall survival by LCS6 genotype and treatment

From: Let-7 miRNA-binding site polymorphism in the KRAS 3UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/− cetuximab

LCS6 genotype

N

Arm

Median months

95% CI

Interaction P value

Progression-free survival

Wild-type

154

A

7.9

7.2-8.5

0.63

297

B+C

7.7

7.2-8.3

Variant

26

A

7.7

3.8 – 11.6

58

B+C

8.5

7.0-10.0

Overall survival

Wild-type

154

A

20.4

16.5 – 24.2

0.50

297

B+C

18.9

16.9 – 20.9

Variant

26

A

22.3

13.2 – 31.4

 

58

B+C

23.5

19.9 – 27.1