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Table 1 Associations between calpastatin, calpain-1 and calpain-2 protein expression and various clinicopathological variables in the pancreatic cancer cohort

From: Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla

 

Calpain-1

Calpain-2

Calpastatin (cytoplasmic)

Calpastatin (nuclear)

 

Low

High

p value

Low

High

p value

Low

High

p value

Low

High

p value

Age

            

 ≤ 60 years (n=23)

17 (34.7)

4 (30.8)

1.000*

3 (18.8)

18 (37.5)

0.225*

16 (32.0)

4 (33.3)

1.000*

15 (33.3)

5 (29.4)

1.000*

 > 60 years (n=45)

32 (65.3)

9 (69.2)

13 (81.3)

30 (62.5)

34 (68.0)

8 (66.7)

30 (66.7)

12 (70.6)

Tumour size

            

 ≤ 2cm (n=17)

16 (33.3)

1 (7.7)

0.088*

5 (31.3)

12 (25.5)

0.747*

13 (26.5)

3 (25.0)

1.000*

10 (22.7)

6 (35.3)

0.317

 > 2cm (n=50)

32 (66.7)

12 (92.3)

11 (68.8)

35 (74.5)

36 (73.5)

9 (75.0)

34 (77.3)

11 (64.7)

T stage

            

 2 (n=12)

6 (12.2)

3 (23.1)

0.335

2 (12.5)

9 (18.8)

0.576

8 (16.0)

3 (25.0)

0.380

8 (17.8)

3 (17.6)

0.766

 3 (n=54)

42 (85.7)

9 (69.2)

14 (87.5)

37 (77.1)

41 (82.0)

8 (66.7)

36 (80.0)

13 (76.5)

 4 (n=2)

1 (2.0)

1 (7.7)

0 (0.0)

2 (4.2)

1 (2.0)

1 (8.3)

1 (2.2)

1 (5.9)

N stage

            

 Negative (n=22)

17 (35.4)

4 (33.3)

1.000*

3 (18.8)

18 (39.1)

0.220*

15 (30.6)

5 (45.5)

0.481*

14 (31.8)

6 (37.5)

0.760*

 Positive (n=44)

31 (64.6)

8 (66.7)

13 (81.3)

28 (60.9)

34 (69.4)

6 (54.5)

30 (68.2)

10 (62.5)

Vascular invasion

            

 absent (n=24)

19 (38.8)

4 (30.8)

0.751*

3 (18.8)

20 (41.7)

0.136*

19 (38.0)

4 (33.3)

1.000*

15 (33.3)

8 (47.1)

0.318

 present (n=44)

30 (61.2)

9 (69.2)

13 (81.3)

28 (58.3)

31 (62.0)

8 (66.7)

30 (66.7)

9 (52.9)

Perineural invasion

            

 absent (n=14)

8 (16.3)

5 (38.5)

0.122*

1 (6.3)

12 (25.0)

0.157*

11 (22.0)

2 (16.7)

1.000*

10 (22.2)

3 (17.6)

1.000*

 present (n=54)

41 (83.7)

8 (61.58)

15 (93.8)

36 (75.0)

39 (78.0)

10 (83.3)

35 (77.8)

14 (82.4)

  1. The frequency of observed clinicopathological variables is noted next to the variable subgroup; one case did not have available data for tumour size. The P values are resultant from Pearson Chi Square test of association (χ2) or Fisher’s Exact test in a 2×2 table if a cell count was less than 5 (indicated by *). Significant P values are indicated by bold font.
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BMC Cancer

ISSN: 1471-2407

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