Genotypic and phenotypic analysis of familial male breast cancer shows under representation of the HER2 and basal subtypes in BRCA-associated carcinomas

Table 5 Second non-breast primary malignancies

Gene	Mutation	2nd tumour	Diagnosis relative to Breast Primary (years)
BRCA2	BRCA2 2988 del C (STOP 959)	Ascending Colon - Adenocarcinoma	15.5
BRCA2	BRCA2 698_702 del AGTCA (STOP 180)	Prostate - Acinar Adenocarcinoma	0.8
BRCA2	BRCA2 8168_8169 ins C (STOP 2661)	Prostate - Acinar Adenocarcinoma	1.4
BRCA2	BRCA2 del exons 1_27	Parotid gland - Oxyphilic adenocarcinoma	6.2
BRCA2	BRCA2 IVS 7–1 G>A	Lung - squamous cell carcinoma	13.8
BRCAX		Adenocarcinoma - unknown primary	3.0
BRCAX		Lung – Carcinoma not otherwise specified.	9.4
BRCAX		Prostate - Acinar Adenocarcinoma	9.5
BRCAX		Prostate - Acinar Adenocarcinoma	3.0 years prior to breast cancer
BRCAX		Prostate - Acinar Adenocarcinoma	1.3 years prior to breast cancer

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