Figure 2

Venn diagrams of transcripts with greater SBS frequencies and genes with cancer somatic mutations. Numbers represent NCBI gene ID. Venn diagram areas are proportional to gene ID numbers. (a) Left circle = COSMIC (v56) census of 422 somatically mutated genes in cancer, right circle = transcripts with greater SBS frequencies in cancer than in healthy cells in L-SAGE experiments. Nine transcripts were common to both lists. For each of these 9 transcripts, no known cancer-related somatic mutations altered the 17 base NlaIII tag. (b) Right circle = COSMIC (v56) census of 422 somatically mutated genes in cancer. Left circle = transcripts with greater SBS frequencies in cancer than in healthy cells in Tag-seq experiments. Sixty eight transcripts were common to both lists. For each of these 68 transcripts, no known cancer related somatic mutations altered the 17 base NlaIII tag.