Figure 3
MV-NIS treatment with and without 131 I prolongs survival in mouse models of medulloblastoma. A. Experimental design of the localized medulloblastoma MV-NIS + 131I survival study. B. Kaplan-Meier survival analysis of mice with localized medulloblastoma tumors treated with 2 × 105 TCID50 MV-NIS seven days post tumor implantation. The mice were subsequently given a 37 MBq dose of 131I by IP injection at 24, 48, or 72 hours following MV-NIS treatment. The 131I-only mice were given radioiodine five days following tumor implantation. Mice denoted as controls were treated with OptiMEM. C. Survival analysis of mice with disseminated tumors. MV-NIS treatment was administered three days after tumor implantation