Table 2 Top 10 cell cycle genes up- and down-regulated in MCF10DCIS cells after Cl-amidine treatment
From: Identification of PADI2 as a potential breast cancer biomarker and therapeutic target
Symbol | Description | Fold change | p-value |
|---|---|---|---|
Genes upregulated | Â | Â | Â |
CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 17.68 | 1.06E-03 |
GADD45A | Growth arrest and DNA-damage-inducible, alpha | 13.53 | 3.57E-03 |
ATM | Ataxia telangiectasia mutated | 9.61 | 6.91E-04 |
DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 8.87 | 2.41E-04 |
HERC5 | Hect domain and RLD 5 | 8.20 | 2.31E-03 |
RAD17 | RAD17 homolog (S. pombe) | 7.50 | 2.20E-05 |
CUL2 | Cullin 2 | 6.57 | 7.37E-04 |
CCNE1 | Cyclin E1 | 6.18 | 5.51E-04 |
ATR | Ataxia telangiectasia and Rad3 related | 5.83 | 1.77E-04 |
CCNT2 | Cyclin T2 | 5.68 | 1.15E-04 |
Genes downregulated | Â | Â | Â |
MCM5 | Minichromosome maintenance complex component 5 | −8.45 | 3.23E-02 |
CDK1 | Cyclin-dependent kinase 1 | −8.14 | 2.88E-03 |
CDC20 | Cell division cycle 20 homolog (S. cerevisiae) | −7.90 | 2.00E-06 |
GTSE1 | G-2 and S-phase expressed 1 | −6.62 | 4.84E-03 |
MCM2 | Minichromosome maintenance complex component 2 | −6.40 | 7.55E-04 |
MKI67 | Antigen identified by monoclonal antibody Ki-67 | −5.11 | 7.60E-05 |
CCNF | Cyclin F | −5.07 | 1.10E-02 |
BIRC5 | Baculoviral IAP repeat containing 5 (Survivin) | −4.49 | 1.10E-02 |
BCL2 | B-cell CLL/lymphoma 2 | −4.14 | 1.70E-05 |
CCND2 | Cyclin D2 | −3.74 | 3.95E-02 |