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Table 3 Correlation of biomarkers with therapy response

From: Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation Therapy

   Responder Non-Responder  
Marker Time [hours] Median Range Median Range p-Value
Nucleosomes
[ng/mL]
0 198.5 17.4-1624 174.7 5.0-1617 0.991
  24 239.1 55.6-1225 844.8 21.7-4334 0.003
  48 677.2 51.7-2095 594.9 133.3-2547 0.851
CYFRA 21-1
[ng/mL]
0 6.9 0.8-32.8 14.0 1.3-246.0 0.031
  24 28.4 1.0-118.0 30.8 2.9-811.0 0.493
  48 19.6 1.5-404.0 28.5 2.6-638.0 0.293
CEA
[ng/mL]
0 162.0 4.0-986.0 557.0 2.0-31620 0.037
  24 265.5 2.6-5011 540.5 1.6-36120 0.087
  48 229.5 2.2-4073 524.0 1.6-37550 0.063
CA 19-9
[U/L]
0 18.6 2.4-159.0 148.0 2.4-11530 0.001
  24 17.9 2.5-298.0 158.0 2.4-18550 0.004
  48 20.9 2.4-260.0 187.5 2.3-17000 0.002
LDH
[U/L]
0 349.0 178.0-544.0 529.5 220.0-3068 0.011
  24 450.0 143.0-1117 532.0 148.0-2923 0.522
  48 572.0 142.0-1488 607.5 168.0-3585 0.434
CRP
[mg/dL]
0 0.9 0.3-5.1 2.4 0.1-20.3 0.227
  24 1.1 0.1-2.8 2.8 0.2-21.8 0.159
  48 4.4 0.1-16.3 4.6 0.3-15.1 0.507
AST
[U/L]
0 37.5 24.0-94.0 56.0 24.0-190.0 0.037
  24 111.0 32.0-169.0 69.0 15.0-339.0 0.782
  48 85.0 33. 0-179.0 66.0 19.0-317.0 0.912
ALT
[U/L]
0 38.0 15.0-63.0 30.0 15.0-268.0 0.658
  24 52.0 26.0-131.0 37.0 14.0-178.0 0.108
  48 54.0 23.0-112.0 34.0 13.0-136.0 0.113
GGT
[U/L]
0 183.5 44. 0-432.0 189.0 33.0-712.0 0.782
  24 168.5 46.0-391.0 164.0 31.0-577.0 0.965
  48 177.5 60.0-406.0 170.0 31.0-653.0 0.903
AP
[U/L]
0 153.0 89.0-569.0 193.0 81.0-742.0 0.559
  24 156.0 78.0-588.0 151.0 63.0-655.0 0.707
  48 156.0 77.0-504.0 164.0 61. 0-630.0 0.674
Bilirubin
[mg/dL]
0 0.7 0.3-1.4 0.8 0.3-1.9 0.438
  24 0.9 0.4-1.7 1.0 0.4-2.2 0.920
  48 1.1 0.5-2.4 1.2 0.4-2.8 0.799
CHE
[kU/L]
0 8.3 4.9-11.1 6.5 2.8-10.8 0.017
  24 7.1 5.1-11.1 5.7 2.8-10.4 0.009
  48 6.9 4.5-10.5 5.3 2.3-9.7 0.006
Amylase
[U/L]
0 64.5 20.0-105.0 54.0 24.0-136.0 0.346
  24 45.5 21.0-79.0 44.0 20.0-429.0 0.833
  48 50.5 20.0-58.0 46.0 23.0-519.0 0.842
Lipase
[U/L]
0 27.0 3.0-149.0 25.0 3.0-263.0 0.725
  24 17.5 4.0-33.0 18.0 3.0-585.0 0.773
  48 16.5 3.0-42.0 22.0 3.0-495.0 0.330
  1. P-values (by Wilcoxon-test) are shown for the various response groups.
  2. There was a significant correlation between therapy response and survival time in this setting (s = 0.034). (Figure 2A).