Table 3 Interactions between apoE genotypes and selected demographic and lifestyle variables on GC risk
Variables | Cases | Controls | Any e2 | Cases | Controls | Any e4 |
|---|---|---|---|---|---|---|
OR (95% CI)† | OR (95% CI)† | |||||
Gender | ||||||
Female, e3/e3 | 51 (34.69) | 96 (65.31) | 1* | 51 (34.69) | 96 (65.31) | 1* |
Female, variant | 8 (27.59) | 21 (72.41) | 0.58 (0.20 – 1.65) | 12 (24.00) | 38 (76.00) | 0.55 (0.23 – 1.32) |
Male, e3/e3 | 57 (26.64) | 157 (73.36) | 0.48 (0.27 – 0.88) | 57 (26.64) | 157 (73.36) | 0.49 (0.27 - 0.89) |
Male, variant | 7 (12.96) | 47 (87.04) | 0.49 (0.11 – 2.18) | 14 (26.92) | 38 (73.08) | 1.52 (0.44 – 5.27) |
P value for interaction° | 0.347 | 0.660 | ||||
Age | ||||||
<60 years, e3/e3 | 25 (17.73) | 116 (82.27) | 1* | 25 (17.73) | 116 (82.27) | 1* |
<60 years, variant | 4 (12.50) | 28 (87.50) | 0.35 (0.07 – 1.68) | 7 (21.21) | 26 (78.79) | 0.70 (0.18 – 2.66) |
≥60 years, e3/e3 | 84 (38.01) | 137 (61.99) | 2.85 (1.53 – 5.28) | 84 (38.01) | 137 (61.99) | 2.84 (1.54 - 5.26) |
≥60 years, variant | 11 (21.57) | 40 (78.43) | 1.24 (0.21 – 7.26) | 20 (28.57) | 50 (71.43) | 0.97 (0.21 – 4.36) |
P value for interaction | 0.807 | 0.964 | ||||
Alcohol drinking | ||||||
Never, e3/e3 | 45 (24.06) | 142 (75.94) | 1* | 45 (24.06) | 142 (75.94) | 1* |
Never, variant | 5 (12.50) | 35 (87.50) | 0.29 (0.08 – 1.04) | 12 (18.18) | 54 (81.82) | 0.62 (0.28 – 1.37) |
Ever, e3/e3 | 64 (36.57) | 111 (63.43) | 1.59 (0.88 – 2.86) | 64 (36.57) | 111 (63.43) | 1.46 (0.81 – 2.62) |
Ever, variant | 10 (23.26) | 33 (76.74) | 1.78 (0.37 – 8.50) | 15 (40.54) | 22 (59.46) | 1.28 (0.35 – 4.66) |
P value for interaction | 0.468 | 0.707 | ||||
Smoking status | ||||||
Never, e3/e3 | 54 (29.03) | 132 (70.97) | 1* | 54 (29.03) | 132 (70.97) | 1* |
Never, variant | 8 (20.51) | 31 (79.49) | 0.48 (0.18 – 1.28) | 13 (20.00) | 52 (80.00) | 0.53 (0.23 – 1.23) |
Ever, e3/e3 | 54 (31.40) | 118 (68.60) | 1.41 (0.80 – 2.50) | 54 (31.40) | 118 (68.60) | 1.39 (0.79 – 2.45) |
Ever, variant | 7 (16.28) | 36 (83.72) | 0.68 (0.15 – 2.98) | 13 (36.11) | 23 (63.89) | 1.98 (0.59 – 6.73) |
P value for interaction | 0.609 | 0.271 | ||||
Fruit and vegetables intake | ||||||
Low, e3/e3 | 28 (29.47) | 67 (70.53) | 1* | 28 (29.47) | 67 (70.53) | 1* |
Low ,variant | 2 (9.09) | 20 (90.91) | 0.14 (0.02 – 0.87) | 9 (32.14) | 19 (67.86) | 0.84 (0.28 – 2.49) |
High, e3/e3 | 78 (31.08) | 173 (68.92) | 1.17 (0.61 – 2.23) | 78 (31.08) | 173 (68.92) | 1.12 (0.59 – 2.13) |
High, variant | 11 (19.30) | 46 (80.70) | 2.83 (0.38 – 21.05) | 16 (22.86) | 54 (77.14) | 0.62 (0.16 – 2.37) |
P value for interaction | 0.309 | 0.487 |