Table 4 Survival analysis for all cause and colorectal cancer mortality by statin intake
All cause mortality | No of events | Persons at risk | Log rank test | Unadjusted Analysis | Adjusted for AJCC | Multivariable adjusted analysis | |||
|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | HR | 95% CI | HR | 95%CI | ||||
Statin use: at least 1 prescription | |||||||||
No | 91 | 251 | 1.00 | 1.00 | 1.00 | ||||
Yes | 15 | 57 | 0.11 | 0.64 | 0.37, 1.10 | 0.65 | 0.37, 1.15 | 0.58 | 0.33, 1.03 |
P = 0.11 | P = 0.14 | P = 0.07 | |||||||
Statin use: at least 1 prescription dispensed before recruitment | |||||||||
No | 91 | 251 | 1.00 | 1.00 | 1.00 | ||||
Yes | 8 | 26 | 0.62 | 0.83 | 0.40, 1.71 | 0.76 | 0.32, 1.38 | 0.59 | 0.28, 1.24 |
P = 0.62 | P = 0.28 | P = 0.16 | |||||||
Statin use: at least 1 prescription dispensed after recruitment | |||||||||
No | 91 | 251 | 1.00 | 1.00 | 1.00 | ||||
Yes | 7 | 31 | 0.08 | 0.51 | 0.23, 1.09 | 0.67 | 0.29, 1.54 | 0.61 | 0.26, 1.41 |
P = 0.08 | P = 0.34 | P = 0.24 | |||||||
Statin use: 2+ prescription | |||||||||
No | 94 | 259 | 1.00 | 1.00 | 1.00 | ||||
Yes | 12 | 49 | 0.09 | 0.59 | 0.33, 1.08 | 0.63 | 0.34, 1.15 | 0.57 | 0.31, 1.05 |
P = 0.09 | P = 0.13 | P = 0.07 | |||||||
Statin use: 2+ prescription dispensed before recruitment | |||||||||
No | 94 | 259 | 1.00 | 1.00 | 1.00 | ||||
Yes | 8 | 25 | 0.70 | 0.87 | 0.42, 1.79 | 0.70 | 0.34, 1.45 | 0.64 | 0.31, 1.34 |
P = 0.70 | P = 0.34 | P = 0.24 | |||||||
Statin use: 2+ prescription dispensed after recruitment | |||||||||
No | 94 | 259 | 1.00 | 1.00 | 1.00 | ||||
Yes | 4 | 24 | 0.04 | 0.36 | 0.13, 0.99 | 0.54 | 0.20, 1.49 | 0.49 | 0.18, 1.36 |
P = 0.05 | P = 0.24 | P = 0.17 | |||||||
Colorectal cancer mortality | HR | 95% CI | HR | 95% CI | HR | 95%CI | |||
Statin use: at least 1 prescription | |||||||||
No | 79 | 251 | 1.00 | 1.00 | 1.00 | ||||
Yes | 12 | 57 | 0.09 | 0.60 | 0.32, 1.09 | 0.61 | 0.32, 1.15 | 0.56 | 0.29, 1.07 |
P = 0.09 | P = 0.13 | P = 0.08 | |||||||
Statin use: at least 1 prescription dispensed before diagnosis | |||||||||
No | 79 | 251 | 1.00 | 1.00 | 1.00 | ||||
Yes | 7 | 26 | 0.66 | 0.84 | 0.39, 1.82 | 0.65 | 0.30, 1.42 | 0.60 | 0.327, 1.32 |
P = 0.66 | P = 0.28 | P = 0.20 | |||||||
Statin use: at least 1 prescription dispensed after | |||||||||
No | 79 | 251 | 1.00 | 1.00 | 1.00 | ||||
Yes | 5 | 31 | 0.05 | 0.42 | 0.17, 1.05 | 0.58 | 0.21, 1.60 | 0.54 | 0.19, 1.50 |
P = 0.06 | P = 0.29 | ||||||||
Statin use: 2+ prescription | |||||||||
No | 82 | 259 | 1.00 | 1.00 | 1.00 | ||||
Yes | 9 | 49 | 0.06 | 0.52 | 0.26, 1.03 | 0.56 | 0.28, 1.11 | 0.51 | 0.25, 1.03 |
P = 0.06 | P = 0.10 | P = 0.06 | |||||||
Statin use: 2+ prescription dispensed before recruitment | |||||||||
No | 82 | 259 | 1.00 | 1.00 | 1.00 | ||||
Yes | 7 | 25 | 0.73 | 0.87 | 0.40, 1.88 | 0.67 | 0.31, 1.48 | 0.64 | 0.26, 1.40 |
P = 0.73 | P = 0.33 | P = 0.26 | |||||||
Statin use: 2+ prescription dispensed after recruitment | |||||||||
No | 82 | 259 | 1.00 | 1.00 | 1.00 | ||||
Yes | 2 | 24 | 0.02 | 0.21 | 0.05, 0.86 | 0.35 | 0.09, 1.45 | 0.33 | 0.08, 1.35 |
P = 0.03 | P = 0.15 | P = 0.12 | |||||||