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Table 4 Response to induction chemotherapy

From: Phase I trial of split-dose induction docetaxel, cisplatin, and 5-fluorouracil (TPF) chemotherapy followed by curative surgery combined with postoperative radiotherapy in patients with locally advanced oral and oropharyngeal squamous cell cancer (TISOC-1)

Assessment parameter

Number of patients (%),N = 18

Clinicoradiologic assessment after first cycle of induction chemotherapy

HPV-

HPV+

all patients

N =15

N = 3

N =18

CR

1

(7)

1

(33)

2

(11)

PR

11

(73)

2

(67)

13

(72)

SD

2

(13)

  

2

(11)

PD

1

   

1

(6)

Clinicoradiologic assessment after third cycle of induction chemotherapy

CR

3

(25)

    

PR

9

(75)

    

Histopathologic result

1 cycle

3 cycles

all patients

pCR of primary tumor

1

(6)

8

(44)

9

(50)

pCR of neck metastasis*

2

(14)

4

(29)

6

(33)

pCR of primary and neck*

1

(7)

4

(29)

5

(27)

Histopathologic result

level 0

level -1

all patients

N =12

N = 6

N =18

pCR of primary tumor

6

(50)

3

(50)

9

(50)

pCR of neck metastasis*

5

(42)

1

(17)

6

(33)

pCR of primary and neck*

4

(33)

1

(17)

5

(27)

yTNM 

HPV-

HPV+

all patients

N =15

N = 3

N =18

ypT0ypN0

3

(20)

3

(100)

6

(33)

ypT0ypN1

1

(7)

  

1

(6)

ypT0ypN2

2

(13)

  

2

(11)

ypT1ypN0

2

(13)

  

2

(11)

ypT1ypN1

2

(13)

  

2

(11)

ypT1ypN2

1

(7)

  

1

(6)

ypT2ypN2

1

(7)

  

1

(6)

ypT3ypN0

1

(7)

  

1

(6)

ypT4ypN0

1

(7)

  

1

(6)

ypT4ypN2

1

(7)

  

1

(6)

Histopathologic risk classification

Low risk

14

(78)

    

High risk

4

(22)

    
  1. *4 patients presented with cN0, therefore only 14 patients went into this calculation (in level 0: 1 patient; in level −1: 3 patients).