Figure 1
From: Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma
Tbx3 mRNA and protein levels are increased in HNSCC tissues. Tissues from cancerous and adjacent normal areas were excised from patients who were diagnosed with HNSCC. RNA was isolated and mRNA levels of Tbx3 (A) and PTEN (B) were quantified using TaqMan probes. Results were normalized to β-Actin mRNA levels. The sign “*”denotes for statistically significant increase and decrease with respect to the normal tissue mRNA levels (p<0.001). (C) Laryngeal squamous cell carcinoma tissue sections stained with haemotoxcylin/eosin (HE) (a) and anti-IgG antibody (b) as an isotypic control. Squamous cell carcinoma sections (c) exhibited stronger cytoplasmic and nuclear staining with anti-Tbx3 antibody with respect to the normal epithelium (d) (magnification 100x).