Table 1 Characteristics of studies on the association between MTHFR 677C>T polymorphism and cervical cancer
From: The association between MTHFR 677C>T polymorphism and cervical cancer: evidence from a meta-analysis
Author (year) | Ethnicity | Country | Study design | Cases | Controls | Genotype method† | Genotype frequency (TT:CT:CC) | Confounding factors | PHWE* | Quality score |
|---|---|---|---|---|---|---|---|---|---|---|
Lambropoulos 2003 [43] | Europeans | Greece | Hospital-based case–control study | 21 cases with cervical cancer | 91 non-cancer controls | PCR-RFLP | (case) 2:8:11 (control) 12:37:42 | None | 0.40 | 5 |
Sull 2004 [45] | East Asians | South Korea | Hospital-based case–control study | 246 cases with invasive cervical cancer | 454 healthy controls | PCR-RFLP | (case) 58:115:73 (control) 80:221:153 | Age, weight | 0.99 | 7 |
Zoodsma 2005 [18] | Europeans | Netherlands | Hospital-based case–control study | 636 cases with cervical cancer | 592 unrelated controls | PCR-RFLP | (case) 49:230:357 (control) 57:262:273 | None | 0.61 | 6 |
Kang 2005 [42] | East Asians | South Korea | Hospital-based case–control study | 79 cases with invasive cervical cancer | 74 healthy controls | PCR-RFLP | (case) 20:32:27 (control) 12:32:30 | Age | 0.49 | 7 |
Delgado 2006 [12] | Others | Mexico | Hospital-based case–control study | 70 cases with cervical cancer | 89 non-cancer controls | PCR-RFLP | (case) 18:34:18 (control) 20:49:20 | None | 0.34 | 5 |
Ma 2006 [44] | East Asians | China | Hospital-based case–control study | 111 cases with cervical cancer | 111 controls with hysteromyoma | PCR-RFLP | (case) 38:53:20 (control) 18:60:33 | Age | 0.29 | 4 |
Shekari 2008 [16] | Indians | India | Hospital-based case–control study | 200 cases with cervical cancer | 200 non-cancer controls | PCR-RFLP | (case) 2:28:170 (control) 7:68:125 | Age, menopause | 0.54 | 8 |
Kohaar 2010 [13] | Indians | India | Hospital-based case–control study | 203 cases with cervical cancer | 231 healthy controls | PCR-RFLP | (case) 4:58:141 (control) 5:65:161 | Age | 0.59 | 6 |
Prasad 2011 [15] | Indians | India | Hospital-based case–control study | 62 cases with cervical cancer | 241 non-cancer controls | PCR-RFLP | (case) 0:5:57 (control) 1:12:228 | None | 0.07 | 5 |
Mostowska 2011 [14] | Europeans | Poland | Hospital-based case–control study | 124 cases with cervical cancer | 168 healthy controls | PCR-RFLP | (case) 9:59:56 (control) 18:81:69 | Parity | 0.42 | 7 |
Tong 2011 [17] | East Asians | South Korea | Hospital-based case–control study | 146 cases with advanced cervical cancer | 427 unrelated healthy female volunteers | PCR-RFLP | (case) 28:65:53 (control) 77:198:152 | Age | 0.37 | 8 |