Figure 4

Pharmacokinetic profile of IHL-305 in an ES-2 peritoneal metastasis mouse model. CPT-11 (45 mg/kg: ●) or IHL-305 (45 mg/kg: ○) was intravenously administered at 0 time to mice with peritoneal metastasis. The concentrations of total CPT-11 (tCPT-11), released CPT-11 from the liposome (rCPT-11), SN-38 and SN-38 glucuronide (SN-38G) were determined in (A) blood and (B) ascites.