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Figure 3 | BMC Cancer

Figure 3

From: Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan

Figure 3

siRNA-mediated suppression of CD44 reduces endogenous erbB activity in TamR cells. Treatment of TamR cells with CD44 siRNA resulted in suppression of CD44 mRNA (A) and protein (B, upper panel). Treatment of TamR cells with siRNA delivery lipid (‘L) or a non-targeting siRNA (‘NT’) did not significantly affect CD44 expression compared to untreated control (‘C’) cells. In cells where CD44 expression was suppressed, the activity of EGFR was also reduced.

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