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Table 1 Genotypic and allelic frequencies of the MDM2 SNP285 and SNP309 in BRCA related ovarian cancer, sporadic ovarian cancer and healthy controls

From: Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers

  SNP285 BRCA1related BRCA2related Sporadic disease* Healthy controls*
   n (%) n (%) n (%) n (%)
SNP285 GG 153 (95.0) 58 (96.7) 1260 (93.7) 2 274 (92.3)
  GC 8 (5.0) 2 (3.3) 82 (6.1) 183 (7.4)
  CC 0 (0.0) 0 (0.0) 3 (0.2) 8 (0.3)
  Total 161 (100) 60 (100) 1 345 (100) 2 465 (100)
  G 314 (97.5) 118 (98.3) 2 602 (96.7) 4 731 (96.0)
  C ** 8 (2.5) 2 (1.7) 88 (3.3) 199 (4.0)
SNP309 TT 52 (32.3) 22 (36.7) 515 (38.3) 1 072 (43.5)
  TG 81 (50.3) 32 (53.3) 661 (49.1) 1 093 (44.3)
  GG 28 (17.4) 6 (10.0) 169 (12.6) 300 (12.2)
  Total 161 (100) 60 (100) 1 345 (100) 2 465 (100)
  T 185 (57.5) 76 (63.3) 1 691 (62.9) 3 237 (65.7)
  G ** 137 (42.5) 44 (36.7) 999 (37.1) 1 693 (34.3)
  1. * Previously published data [28].
  2. ** Minor allele.