Table 1 The consecutive changes of some pro-angiogenic factors in the first and re-initiated IFN-α treatment course
Unigene | Gene name | Description | Gene symbol | Control group A | IFN-α treatment group B | Re- initiated control group E | Re- initiated IFN-α group F |
|---|---|---|---|---|---|---|---|
Hs.283749 | NM_001145 | Angiogenin, RNase A family, 5 ribonuclease | ANG | 0.404 | 0.275 | 0.418 | 0.326 |
Hs.2233 | NM_000759 | Colony stimulating factor 3 (granulocyte) | CSF3 | 0.179 | 0.117 | 0.400 | 0.032 |
Hs.419815 | NM_001963 | Epidermal growth factor (beta- urogastrone) | EGF | 0.270 | 0.204 | 0.057 | 0.045 |
Hs.284244 | NM_001006 | Fibroblast growth factor 2 (basic) | FGF2 | 0.236 | 0.163 | 0.014 | 0.011 |
Hs.396530 | NM_000601 | Hepatocyte growth factor | HGF | 0.414 | 0.140 | 0.074 | 0.026 |
Hs.308053 | NM_000618 | Insulin-like growth factor 1 (somatomedin C) | IGF1 | 0.242 | 0.062 | 0.032 | 0.006 |
Hs.624 | NM_000583 | Interleukin 8 | IL-8 | 0.235 | 0.130 | 0.020 | 0.017 |
Hs.367877 | NM_004530 | Matrix metalloproteinase 2 | MMP2 | 0.171 | 0.071 | 0.014 | 0.010 |
Hs.151738 | NM_004994 | Matrix metalloproteinase 9 | MMP9 | 0.179 | 0.069 | 0.012 | 0.010 |
Hs.376032 | NM_002607 | Platelet-derived growth factor alpha polypeptide | PDGFA | 0.212 | 0.054 | 0.131 | 0.200 |
Hs.252820 | NM_002632 | Placental growth factor | PGF | 0.050 | 0.021 | 0.040 | 0.008 |
Hs.196384 | NM_000963 | Prostaglandin-endoperoxide synthase 2 | PTGS2 | 0.137 | 0.063 | 0.069 | 0.041 |
Hs.170009 | NM_003236 | Transforming growth factor, alpha | TGFA | 0.169 | 0.082 | 0.080 | 0.028 |
Hs.241570 | NM_000594 | Tumor necrosis factor (TNF superfamily, member 2) | TNG | 0.076 | 0.044 | 0.097 | 0.026 |
Hs.73793 | NM_003376 | Vascular endothelial growth factor | VEGF | 0.203 | 0.100 | 0.199 | 0.092 |