Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1metabolic genes and risk of lung cancer in Asturias

Table 5 Analysis of interaction between polymorphisms and worker in list A occupation in lung cancer risk

	Cases/Controls n(%)/n(%)	p^a	Unadjusted	Adjusted^b	p-interaction
	Cases/Controls n(%)/n(%)	p^a	OR [95% CI]	OR [95% CI]	p-interaction
**CYP1A1 List A*** ^c
T/T–No list A	494(62.6)/544(68.9)	0.006	Reference	Reference	0.128
T/C+C/C–No list A	147(18.6)/141(17.9)		1.15 [0.88-1.49]	1.04 [0.77-1.39]
T/T–List A	114(14.4)/88(11.1)		1.43 [1.05-1.93]	1.15 [0.82-1.62]
T/C+C/C–List A	34(4.3)/16(2.0)		2.34 [2.27-4.30]	2.20 [1.11-4.35]
*GSTM* 1 * List A
present/present–No list A	308(39.7)/317(40.8)	0.015	Reference	Reference	0.700
>=1 null allele–No list A	322(41.5)/357(46.0)		0.93 [0.75-1.15]	0.97 [0.75-1.24]
present/present–List A	67(8.6)/41(5.3)		1.68 [1.10-2.56]	1.38 [0.86-2.22]
>=1 null allele–List A	79(10.2)/61(7.9)		1.33 [0.92-1.93]	1.18 [0.78-1.79]
*GSTT* 1 * List A
present/present–No list A	501(64.6)/525(67.6)	0.015	Reference	Reference	0.439
>=1 null allele–No list A	129(16.6)/149(19.2)		0.91 [0.70-1.18]	0.81 [0.60-1.09]
present/present–List A	117(15.1)/86(11.1)		1.43 [1.05-1.93]	1.21 [0.86-1.70]
>=1 null allele–List A	29(3.7)/16(2.1)		1.90 [1.02-3.55]	1.33 [0.67-2.64]
*GSTP* 1 * List A
Ile/Ile–No list A	289(36.7)/289(36.7)	0.010	Reference	Reference	0.815
Ile/Val+Val/Val–No list A	350(44.4)/396(50.2)		0.88 [0.71-1.10]	0.84 [0.66-1.08]
Ile/Ile–List A	63(8.0)/41(5.2)		1.54 [1.00-2.36]	1.38 [0.85-2.22]
Ile/Val+Val/Val–List A	86(10.9)/62(7.9)		1.39 [0.96-2.00]	1.08 [0.72-1.62]

^a Chi-squared p-value.
^b Adjusted by age, family history of any cancer, and pack-years (non-smoker, <37PY, ≥37PY).
^c List A includes occupations known to be associated with lung cancer.

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