Cases/Controls n(%)/n(%) | pa | Unadjusted | Adjustedb | p-interaction | |
---|---|---|---|---|---|
OR [95% CI] | OR [95% CI] | ||||
CYP1A1 * PY | |||||
T/T–Non-smokers | 40(5.1)/182(23.1) | <0.001 | Reference | Reference | 0.071 |
T/C+C/C–Non-smokers | 11(1.4)/40(5.1) | 1.25 [0.59-2.65] | 1.16 [0.59-2.52] | ||
T/T–Smokers<37PY | 139(17.6)/262(33.2) | 2.41 [1.61-3.62] | 2.47 [1.64-3.71] | ||
T/C+C/C–Smokers<37PY | 32(4.1)/77(9.8) | 1.89 [1.10-3.25] | 1.83 [1.06-3.17] | ||
T/T–Smokers>=37PY | 429(54.4)/187(23.7) | 10.44 [6.78-16.07] | 10.14 [6.46-14.99] | ||
T/C+C/C–Smokers>=37PY | 138(17.5)/40(5.1) | 15.70 [8.52-28.94] | 15.38 [9.32-25.38] | ||
GSTM 1 * PY | |||||
present/present–Non-smokers | 26(3.3)/102(13.2) | <0.001 | Reference | Reference | 0.544 |
>=1 null allele–Non-smokers | 25(3.2)/119(15.3) | 0.82 [0.45-1.52] | 0.82 [0.44-1.52] | ||
present/present–Smokers<37PY | 70(9.0)/149(19.2) | 1.84 [1.09-3.10] | 1.87 [1.10-3.17] | ||
>=1 null allele–Smokers<37PY | 96(12.4)/182(23.5) | 2.07 [1.25-3.42] | 2.10 [1.26-3.51] | ||
present/present–Smokers>=37PY | 279(35.9)/106(13.7) | 10.33 [5.98-17.84] | 10.27 [6.24-16.84] | ||
>=1 null allele–Smokers>=37PY | 280(36.0)/117(15.1) | 9.39 [5.49-16.05] | 9.00 [5.49-14.73] | ||
GSTT 1 * PY | |||||
present/present–Non-smokers | 40(5.1)/185(23.9) | <0.001 | Reference | Reference | 0.060 |
>=1 null allele–Non-smokers | 11(1.4)/36(4.6) | 1.41 [0.66-3.02] | 1.44 [0.67-3.09] | ||
present/present–Smokers< 37PY | 129(16.6)/264(34.1) | 2.26 [1.50-3.40] | 2.31 [1.53-3.50] | ||
>=1 null allele–Smokers< 37PY | 37(4.8)/67(8.6) | 2.55 [1.49-4.38] | 2.62 [1.52-4.50] | ||
present/present–Smokers>=37PY | 449(57.9)/161(20.8) | 12.90 [8.25-20.17] | 12.72 [8.55-18.91] | ||
>=1 null allele–Smokers>=37PY | 110(14.2)/62(8.0) | 8.21 [4.85-13.87] | 8.05 [5.02-12.91] | ||
GSTP 1 * PY | |||||
Ile/Ile – Non-smokers | 22(2.8)/93(11.8) | <0.001 | Reference | Reference | 0.344 |
Ile/Val+Val/Val – Non-smokers | 29(3.7)/127(16.1) | 0.97 [0.52-1.79] | 0.95 [0.51-1.78] | ||
Ile/Ile–Smokers< 37PY | 84(10.7)/141(17.9) | 2.52 [1.46-4.36] | 2.69 [1.55-4.66] | ||
Ile/Val+Val/Val–Smokers<37PY | 87(11.0)/199(25.3) | 1.85 [1.08-3.15] | 1.79 [1.04-3.08] | ||
Ile/Ile–Smokers > =37PY | 246(31.2)/95(12.1) | 10.95 [6.06-19.76] | 10.64 [6.24-18.15] | ||
Ile/Val+Val/Val–Smokers>=37PY | 320(40.6)/132(16.8) | 10.25 [5.85-19.95] | 10.05 [5.98-16.90] |