Table 4 Analysis of interaction between polymorphisms and tobacco consumption in lung cancer risk

CYP1A1 * PY

T/T–Non-smokers

40(5.1)/182(23.1)

<0.001

Reference

Reference

0.071

T/C+C/C–Non-smokers

11(1.4)/40(5.1)

1.25 [0.59-2.65]

1.16 [0.59-2.52]

T/T–Smokers<37PY

139(17.6)/262(33.2)

2.41 [1.61-3.62]

2.47 [1.64-3.71]

T/C+C/C–Smokers<37PY

32(4.1)/77(9.8)

1.89 [1.10-3.25]

1.83 [1.06-3.17]

T/T–Smokers>=37PY

429(54.4)/187(23.7)

10.44 [6.78-16.07]

10.14 [6.46-14.99]

T/C+C/C–Smokers>=37PY

138(17.5)/40(5.1)

15.70 [8.52-28.94]

15.38 [9.32-25.38]

GSTM 1 * PY

present/present–Non-smokers

26(3.3)/102(13.2)

<0.001

Reference

Reference

0.544

>=1 null allele–Non-smokers

25(3.2)/119(15.3)

0.82 [0.45-1.52]

0.82 [0.44-1.52]

present/present–Smokers<37PY

70(9.0)/149(19.2)

1.84 [1.09-3.10]

1.87 [1.10-3.17]

>=1 null allele–Smokers<37PY

96(12.4)/182(23.5)

2.07 [1.25-3.42]

2.10 [1.26-3.51]

present/present–Smokers>=37PY

279(35.9)/106(13.7)

10.33 [5.98-17.84]

10.27 [6.24-16.84]

>=1 null allele–Smokers>=37PY

280(36.0)/117(15.1)

9.39 [5.49-16.05]

9.00 [5.49-14.73]

GSTT 1 * PY

present/present–Non-smokers

40(5.1)/185(23.9)

<0.001

Reference

Reference

0.060

>=1 null allele–Non-smokers

11(1.4)/36(4.6)

1.41 [0.66-3.02]

1.44 [0.67-3.09]

present/present–Smokers< 37PY

129(16.6)/264(34.1)

2.26 [1.50-3.40]

2.31 [1.53-3.50]

>=1 null allele–Smokers< 37PY

37(4.8)/67(8.6)

2.55 [1.49-4.38]

2.62 [1.52-4.50]

present/present–Smokers>=37PY

449(57.9)/161(20.8)

12.90 [8.25-20.17]

12.72 [8.55-18.91]

>=1 null allele–Smokers>=37PY

110(14.2)/62(8.0)

8.21 [4.85-13.87]

8.05 [5.02-12.91]

GSTP 1 * PY

Ile/Ile – Non-smokers

22(2.8)/93(11.8)

<0.001

Reference

Reference

0.344

Ile/Val+Val/Val – Non-smokers

29(3.7)/127(16.1)

0.97 [0.52-1.79]

0.95 [0.51-1.78]

Ile/Ile–Smokers< 37PY

84(10.7)/141(17.9)

2.52 [1.46-4.36]

2.69 [1.55-4.66]

Ile/Val+Val/Val–Smokers<37PY

87(11.0)/199(25.3)

1.85 [1.08-3.15]

1.79 [1.04-3.08]

Ile/Ile–Smokers > =37PY

246(31.2)/95(12.1)

10.95 [6.06-19.76]

10.64 [6.24-18.15]

Ile/Val+Val/Val–Smokers>=37PY

320(40.6)/132(16.8)

10.25 [5.85-19.95]

10.05 [5.98-16.90]