Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1metabolic genes and risk of lung cancer in Asturias

Table 2 Analysis of polymorphisms and lung cancer risk

Metabolic enzyme Gen SNP	Genotype	Cases	Controls	p^a	Unadjusted OR	Adjusted^b OR
Metabolic enzyme Gen SNP	Genotype	n (%)	n (%)	p^a	[95% CI]	[95% CI]
Phase I *CYP1A1* MspI T6235C	T/T	608 (77.1)	632 (80.1)	0.203	Reference	Reference
	T/C	172 (21.8)	145 (18.4)		1.23 [0.96-1.58]	1.16 [0.87-1.53]
	C/C	9 (1.1)	12 (1.5)		0.78 [0.33-1.86]	0.83 [0.31-2.20]
	T/C + C/C	181 (22.9)	157 (19.9)	0.141	1.20 [0.94-1.53]	1.13 [0.86-1.49]
Phase II *GSTM1* present/null	present/present	375 (48.3)	358 (46.1)	0.387	Reference	Reference
Phase II *GSTM1* present/null	> = 1 null allele	401 (51.7)	418 (53.9)	0.387	0.92 [0.75-1.12]	0.95 [0.76-1.19]
Phase II *GSTT1* present/null	present/present	618 (79.6)	611 (78.7)	0.662	Reference	Reference
Phase II *GSTT1* present/null	> = 1 null allele	158 (20.4)	165 (21.3)	0.662	0.95 [0.74-1.21]	0.85 [0.64-1.12]
Phase II *GSTP1* Ile105Val	Ile/Ile	352 (44.7)	330 (41.9)	0.391	Reference	Reference
	Ile/Val	339 (43.0)	366 (46.4)		0.87 [0.70-1.07]	0.84 [0.66-1.06]
	Val/Val	97 (12.3)	92 (11.7)		0.99 [0.72-1.36]	0.83 [0.57-1.19]
	Ile/Val + Val/Val	436 (55.3)	458 (58.1)	0.263	0.89 [0.73-1.09]	0.83 [0.66-1.05]

^a Chi-squared p-value.
^b Adjusted by age, pack-years (non-smoker, <37PY, ≥37PY), family history of any cancer, and worker in list A occupation^*.
^* List A includes occupations known to be associated with lung cancer.

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