Schematic diagram of the experimental strategy. Genome-wide association studies were performed for paclitaxel or docetaxel IC50 using 1.3 million SNPs. 147 SNPs were associated with paclitaxel IC50 with p-values < 10-4 and 76 SNPs were associated with IC50 values for both taxanes with p-values < 10-3. Those SNPs were genotyped in 874 lung cancer patients treated with paclitaxel-based chemotherapy. 8 SNPs were found to be consistently associated with both paclitaxel IC50 in LCLs and lung cancer overall survival. Eleven genes which were close to those 8 SNPs were functionally validated using lung cancer cell lines.