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Table 1 Association of clinicopathological parameters and TS or DPD expression

From: Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma

Parameter TS P value DPD P value
  Negative, n (%) Positive, n (%)   Negative, n (%) Positive, n (%)  
Age       
< 65 years (n = 75) 38(38.8) 37(47.4) 0.248 48(46.6) 27(37.0) 0.219
≥65 years (n = 101) 60(61.2) 41(52.6)   55(53.4) 46(63.0)  
Gender       
Male (n = 132) 72(73.5) 60(76.9) 0.599 75(72.8) 57(78.1) 0.482
Female (n = 44) 26(26.5) 18(23.1)   28(27.2) 16(21.9)  
Pathological T stage       
pTa 35 8 <0.001 33 10 0.111
pT1 30 10   20 20
pT2 19 10   18 11
pT3 13 46   30 29
pT4 1 4   2 3
Grade       
G1 0 0 <0.001 0 0 <0.001
G2 60 19   59 20  
G3 38 59   44 53  
LVI       
Negative (n = 108) 82(83.7) 26(33.3) <0.001 68(66.0) 40(54.8) 0.158
Positive (n = 68) 16(16.3) 52(66.7)   35(34.0) 33(45.2)  
Nodal involvement       
Negative (n = 157) 94(95.9) 63(80.8) <0.001 94(91.3) 63(86.3) 0.102
Positive (n = 19) 4(4.1) 15(19.2)   9(8.7) 10(13.7)
Tumor location       
Pelvis (n = 112) 56(57.1) 56(71.8) 0.058 73(70.9) 39(53.4) 0.062
Ureter (n = 64) 42(42.9) 22(28.2)   30(29.1) 34(46.6)  
  1. TS: thymidylate synthase; DPD: dihydropyrimidine dehydrogenase; LVI: lymphovascular invasion.