Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma

Table 1 Association of clinicopathological parameters and TS or DPD expression

Parameter	TS		P value	DPD		P value
	Negative, n (%)	Positive, n (%)		Negative, n (%)	Positive, n (%)
Age
< 65 years (n = 75)	38(38.8)	37(47.4)	0.248	48(46.6)	27(37.0)	0.219
≥65 years (n = 101)	60(61.2)	41(52.6)		55(53.4)	46(63.0)
Gender
Male (n = 132)	72(73.5)	60(76.9)	0.599	75(72.8)	57(78.1)	0.482
Female (n = 44)	26(26.5)	18(23.1)		28(27.2)	16(21.9)
Pathological T stage
pTa	35	8	<0.001	33	10	0.111
pT1	30	10		20	20
pT2	19	10		18	11
pT3	13	46		30	29
pT4	1	4		2	3
Grade
G1	0	0	<0.001	0	0	<0.001
G2	60	19		59	20
G3	38	59		44	53
LVI
Negative (n = 108)	82(83.7)	26(33.3)	<0.001	68(66.0)	40(54.8)	0.158
Positive (n = 68)	16(16.3)	52(66.7)		35(34.0)	33(45.2)
Nodal involvement
Negative (n = 157)	94(95.9)	63(80.8)	<0.001	94(91.3)	63(86.3)	0.102
Positive (n = 19)	4(4.1)	15(19.2)		9(8.7)	10(13.7)	0.102
Tumor location
Pelvis (n = 112)	56(57.1)	56(71.8)	0.058	73(70.9)	39(53.4)	0.062
Ureter (n = 64)	42(42.9)	22(28.2)		30(29.1)	34(46.6)

TS: thymidylate synthase; DPD: dihydropyrimidine dehydrogenase; LVI: lymphovascular invasion.

ISSN: 1471-2407