|
Characteristic
|
Patients < 65 years
|
Patients > 65 years
|
|---|
| | |
Univariate analysis
|
Multivariable analysis
| |
Univariate analysis
|
Multivariable analysis
|
|---|
| |
N
|
HR
|
95% CI
|
P
|
HR
|
95% CI
|
P
|
N
|
HR
|
95% CI
|
P
|
HR
|
95% CI
|
P
|
|---|
|
Age
| | | |
.74
| | | | | | | | | | |
|
< 40
|
33
|
1
| | | | | |
0
| | | | | | |
|
40-50
|
98
|
1.10
|
0.62-1.96
| | | | |
0
| | | | | | |
|
50-60
|
101
|
1.29
|
0.73-2.29
| | | | |
0
| | | | | | |
|
> 60
|
44
|
1.29
|
0.66-2.52
| | | | |
154
| | | | | | |
|
Grade
| | | |
.03
| | |
0.21
| | | |
.01
| | |
.29
|
|
I
|
31
|
1
| | |
1
| | |
24
|
1
| | |
1
| | |
|
II
|
131
|
1.45
|
0.76-2.75
| |
1.06
|
0.40-2.78
| |
74
|
1.73
|
0.66-4.58
| |
1.30
|
0.48-3.58
| |
|
III
|
75
|
2.17
|
1.12-4.20
| |
1.54
|
0.58-4.11
| |
44
|
3.66
|
1.39-9.61
| |
2.01
|
0.70-5.75
| |
|
Histological type
| | | |
.54
| | | | | | |
.53
| | | |
|
Ductal
|
223
|
1
| | | | | |
124
|
1
| | | | | |
|
Other
|
15
|
1.24
|
0.63-2.45
| | | | |
18
|
0.74
|
0.30-1.87
| | | | |
|
Tumor stage
| | | |
< .001
| | |
0.05
| | | |
.03
| | |
.90
|
|
pT1
|
137
|
1
| | |
1
| | |
59
|
1
| | |
1
| | |
|
pT2
|
109
|
1.66
|
1.16-2.37
| |
1.60
|
1.01-2.55
| |
71
|
2.23
|
1.22-4.09
| |
1.16
|
0.56-2.40
| |
|
pT3/4
|
22
|
2.73
|
1.57-4.76
| |
2.04
|
1.07-3.88
| |
18
|
2.11
|
0.82-5.45
| |
1.23
|
0.42-3.63
| |
|
Nodal stage
| | | |
< .001
| | |
< 0.001
| | | |
< .001
| | |
< .001
|
|
Negative
|
204
|
1
| | |
1
| | |
109
|
1
| | |
1
| | |
|
Positive
|
69
|
4.25
|
3.02-5.99
| |
4.44
|
2.89-6.82
| |
36
|
3.94
|
2.28-6.82
| |
3.33
|
1.77-6.24
| |
|
ER status
| | | |
.59
| | | | | | |
.22
| | | |
|
Negative
|
87
|
1
| | | | | |
40
|
1
| | | | | |
|
Positive
|
126
|
0.90
|
0.66-1.32
| | | | |
95
|
1.53
|
0.78-2.98
| | | | |
|
PgR status
| | | |
.78
| | | | | | |
.78
| | | |
|
Negative
|
84
|
1
| | | | | |
55
|
1
| | | | | |
|
Positive
|
123
|
0.95
|
0.64-1.40
| | | | |
81
|
1.08
|
0.61-1.92
| | | | |
|
HER2 status
| | | |
.26
| | | | | | |
.05
| | | |
|
Negative
|
143
|
1
| | | | | |
105
|
1
| | | | | |
|
Positive
|
19
|
1.44
|
0.76-2.71
| | | | |
4
|
0.05
|
0.00-23.3
| | | | |
|
ALDH1 status
| | | |
.01
| | |
0.02
| | | |
.14
| | | |
|
Negative
|
77
|
1
| | |
1
| | |
63
|
1
| | | | | |
|
Positive
|
116
|
1.75
|
1.14-2.68
| |
1.71
|
1.09-2.68
| |
61
|
0.64
|
0.35-1.16
| | | | |
- Abbreviations: N number of patients; HR hazard ratio; ER estrogen receptor; PgR progesterone receptor; HER2 human epidermal growth factor receptor 2; ALDH1 aldehyde dehydrogenase 1
