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Table 2 Univariate and multivariable analysis for relapses free period stratified by age for patients naive to systemic treatment

From: Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer

Characteristic Patients < 65 years Patients > 65 years
   Univariate analysis Multivariable analysis   Univariate analysis Multivariable analysis
  N HR 95% CI P HR 95% CI P N HR 95% CI P HR 95% CI P
Age     .74           
< 40 33 1       0       
40-50 98 1.10 0.62-1.96      0       
50-60 101 1.29 0.73-2.29      0       
> 60 44 1.29 0.66-2.52      154       
Grade     .03    0.21     .01    .29
I 31 1    1    24 1    1   
II 131 1.45 0.76-2.75   1.06 0.40-2.78   74 1.73 0.66-4.58   1.30 0.48-3.58  
III 75 2.17 1.12-4.20   1.54 0.58-4.11   44 3.66 1.39-9.61   2.01 0.70-5.75  
Histological type     .54        .53    
Ductal 223 1       124 1      
Other 15 1.24 0.63-2.45      18 0.74 0.30-1.87     
Tumor stage     < .001    0.05     .03    .90
pT1 137 1    1    59 1    1   
pT2 109 1.66 1.16-2.37   1.60 1.01-2.55   71 2.23 1.22-4.09   1.16 0.56-2.40  
pT3/4 22 2.73 1.57-4.76   2.04 1.07-3.88   18 2.11 0.82-5.45   1.23 0.42-3.63  
Nodal stage     < .001    < 0.001     < .001    < .001
Negative 204 1    1    109 1    1   
Positive 69 4.25 3.02-5.99   4.44 2.89-6.82   36 3.94 2.28-6.82   3.33 1.77-6.24  
ER status     .59        .22    
Negative 87 1       40 1      
Positive 126 0.90 0.66-1.32      95 1.53 0.78-2.98     
PgR status     .78        .78    
Negative 84 1       55 1      
Positive 123 0.95 0.64-1.40      81 1.08 0.61-1.92     
HER2 status     .26        .05    
Negative 143 1       105 1      
Positive 19 1.44 0.76-2.71      4 0.05 0.00-23.3     
ALDH1 status     .01    0.02     .14    
Negative 77 1    1    63 1      
Positive 116 1.75 1.14-2.68   1.71 1.09-2.68   61 0.64 0.35-1.16     
  1. Abbreviations: N number of patients; HR hazard ratio; ER estrogen receptor; PgR progesterone receptor; HER2 human epidermal growth factor receptor 2; ALDH1 aldehyde dehydrogenase 1