Table 4 Serum level of nine serum biomarkers in colon cancer patients in comparison to adenoma cases and healthy control patients

CEA ‡ (ng/mL)

median

1.26

0.51

0.82

inter-quartile range

0.54 – 4.01

0.36 -1.09

0.41 – 1.34

range

0.08 - 444.32

0.14 - 6.05

0.12 - 3.62

p-value

< 0.0001

IL-8 ‡ (pg/mL)

median

27.46

20.47

19.97

inter-quartile range

20.20 – 42.36

16.78 – 26.21

16.20 – 26.52

range

0.00 - 572.58

0.00 - 221.15

0.00 - 158.39

p-value

< 0.0001

VEGF ‡ (pg/mL)

median

77.99

59.94

67.86

inter-quartile range

46.78 – 120.94

34.99 – 98.70

42.95 – 91.41

range

5.02 - 350.38

7.54 - 427.56

10.68 - 178.72

p-value

0.02

M-CSF ‡ (pg/mL)

median

8.27

7.18

6.65

inter-quartile range

6.70 – 12.76

5.31 – 10.26

5.47 – 8.58

range

2.26 - 58.23

2.99 - 72.86

3.50 - 30.55

p-value

0.02

S100A11 ‡ (ng/mL)

median

12.14

10.89

11.93

inter-quartile range

9. 39 – 15.46

7.97 – 14.18

9.61 – 16.05

range

4.37 - 177.68

3.99 - 105.25

6.69 - 56.93

p-value

0.04

NNMT (ng/mL)

median

1.48

1.46

1.63

inter-quartile range

0.72 – 4.23

0.67 – 4.60

0.64 – 7.82

range

0.25 - 70.00*

0.27 - 70.00*

0.28 - 70.00*

p-value

> 0.05

C3a desArg ‡ (ng/mL)

median

708

808

660

inter-quartile range

514 – 906

538 – 1134

344 – 1216

range

140 - 6114

150 - 3316

200 - 3282

p-value

0.04

CD26 ‡ (ng/mL)

median

442

550

614

inter-quartile range

378 – 582

428 – 698

494 – 750

range

184 - 1352

0.00 - 1034

82 – 3980*

p-value

0.0002

CRP ‡ (ng/mL)

median

4018

2086

2020

inter-quartile range

1718 – 9238

1188 – 5260

1208 – 4768

range

778 - 59800*

726 - 59800*

902 - 59800*

p-value

0.006