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Table 3 Comparison of Diagnostic Results of NAB alone and NAB combined with Tumor Markers in 194 Patients

From: Additional diagnostic value of tumor markers in cytological fluid for diagnosis of non-small-cell lung cancer

Diagnostic Method

Sensitivity (%)

Specificity (%)

Accuracy(%)

PPV (%)

NPV (%)

NAB alone

83.5

100.0

88.1

100.0

70.5

NAB+Serum Tumor marker

CYFRA (3.3)

85.6

81.8

84.5

92.2

69.2

CEA (5)

86.3

90.9

87.6

96.0

72.5

SCC (2)

84.2

92.7

86.6

96.7

69.9

NAB+Cytological Tumor marker

    

CYFRA (15.7)

95.0

98.2

95.9

99.2

88.5

CEA (0.6)

92.1

92.7

92.3

97.0

82.3

SCC (0.86)

91.4

70.9

85.6

88.8

76.5

  1. Note-Numbers in parentheses are cut-off levels of tumor markers in ng/mL.
  2. Abbreviations: PPV, positive predictive value; NPV, negative predictive value; CEA, carcinoembryonic antigen; SCC, squamous cell carcinoma; CYFRA, cytokeratin 19 fragments; NAB, needle aspiration biopsy.