Figure 3From: Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization Gene and protein expression levels of doxorubicin to doxorubicinol metabolizing enzymes. (A) Relative changes in expression between MCF-7CC12 and MCF-7DOX2-12 cells were assessed by RTqPCR. Each sample was normalized first to RPS28 for loading and then to the average expression of MCF-7CC12 cells to determine fold change. * p ≤ 0.05, ** p ≤ 0.01. (B) Western blot analysis of AKR1C3 expression in MCF-7DOX2-12 and MCF-7CC12 whole cell lysates.Back to article page