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Table 6 Logistic regression analyses of the impact of clinico-pathological factors and 11q13.3-q13.4 splitting and amplification on LNM

From: Characterization of genetic rearrangements in esophageal squamous carcinoma cell lines by a combination of M-FISH and array-CGH: further confirmation of some split genomic regions in primary tumors

Clinical features LNM Univariate analysis Multivariate analysis
  N0 N1 P value RR (95% CI) P valuea RR (95% CI)
Gender       
 Male 48 61 0.368 1.466 (0.637-3.374) -  
 Female 15 13     
Age       
 < 60 32 38 0.948 0.978 (0.499-1.915) -  
 ≥ 60 31 36     
Tumor size       
 T1, T2 11 9 0.384 1.528 (0.589-3.964) -  
 T3, T4 52 65     
Differentiation       
 G1 16 11 0.295 1.308 (0.792-2.161) -  
 G2 31 43     
 G3 16 20     
Splitting status       
 Non-splitting 44 32 0.004 2.822 (1.384-5.757) 0.026 2.357 (1.110-5.004)
 Splitting 19 39     
Amplification status       
 Non-amp 13 5 0.022 3.588 (1.202-10.712) 0.165 2.265 (0.715-7.175)
 Amp 50 69     
  1. a The P value of each variable which is not significantly correlated with LNM in univariate analysis is indicated with “-” in the multivariate analysis. Multivariate logistic regression analysis is performed using forward procedures.
  2. LNM: lymph node metastasis; RR, relative risk; CI, confidence interval; amp: amplification.