Figure 1

The ten year follow-up of the four study groups, according to disease status at study entry: diabetes free (DF) or prevalent (DP), and cancer free (CF) or prevalent (CP). For the groups that are DF at study entry, diabetes incidence (DI) will be followed and associated with outcomes (green arrows pointing down). For the groups that are DP at study entry, glucose control and diabetes medications will be followed and associated with the outcomes (green arrows pointing to the right). All four groups will be followed for the study outcome: overall and specific cancers, including second primary neoplasms.