Figure 2
From: Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications
Immunohistochemical staining of AMPK-α1, -α2, -β1, and -β2 expressions in ovarian tissues. The over-expression of AMPK-α2 was observed in this representative tumor case. The expression of AMPK-α1 was detected in the cytoplasm only, whereas the expression of AMPK-α2 was detected in both cytoplasm and nucleus (indicated by an arrow). N.B. For AMPK-α1, in this particular tumor sample, AMPK-α1 expression was higher than the normal. This clearly indicated that AMPK-α1 was only expressed in the cytoplasm. Over-expressions of AMPK-β1 and AMPK-β2 were also observed in the two representative tumor cases. Expression of AMPK-β2 was detected in the cytoplasm only, whereas expression of AMPK-β1 was detected in both cytoplasm and cell membrane (indicated by an arrow).