Table 2 Selection of genes differentially expressed in the PDAC xenograft SP versus MP
From: Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine
Gene Symbol | Genbank Accession no. | Gene Name | Fold SP/MP | p-value |
|---|---|---|---|---|
ZAP70 | NM_001079 | zeta-chain (TCR) associated protein kinase 70 kDa | 24.25 | 0.00002 |
PRKCQ | NM_006257 | protein kinase C, theta | 21.56 | 0.00008 |
FASLG | NM_000639 | Fas ligand (TNF superfamily, member 6) | 19.56 | 0.00003 |
LEF1 | NM_000639 | lymphoid enhancer-binding factor 1 | 16.45 | 0.00009 |
PACSIN1 | NM_020804 | protein kinase C and casein kinase substrate in neurons 1 | 12.47 | 0.00015 |
MEOX2 | NM_005924 | mesenchyme homeobox 2 | 8.22 | 0.00060 |
STAT4 | NM_003151 | signal transducer and activator of transcription 4 | 7.46 | 0.00050 |
EMX2 | NM_003151 | empty spiracles homeobox 2 | 6.87 | 0.00006 |
SOX11 | NM_003108 | SRY (sex determining region Y)-box 11 | 6.19 | 0.00029 |
FGF7 | NM_002009 | fibroblast growth factor 7 (keratinocyte growth factor) | 5.74 | 0.00072 |
FOXG1B | NM_005249 | forkhead box G1B | 5.62 | 0.00019 |
PKNOX2 | NM_022062 | PBX/knotted 1 homeobox 2 | 5.58 | 0.00017 |
ITGB3 | NM_000212 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 5.35 | 0.00062 |
KLF12 | NM_007249 | Kruppel-like factor 12 | 5.03 | 0.00048 |
SNAI2 | NM_003068 | snail homolog 2 (Drosophila) | 4.99 | 0.00079 |
TIE1 | NM_005424 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 4.76 | 0.00019 |
IRX2 | AY335940 | iroquois homeobox protein 2 | 4.53 | 0.00010 |
EFNB2 | NM_004093 | ephrin-B2 | 4.23 | 0.00016 |
ETS1 | NM_005238 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 3.95 | 0.00095 |
BCL2L11 | NM_138621 | BCL2-like 11 | 3.68 | 0.00019 |
GRB10 | NM_001001555 | growth factor receptor-bound protein 10 | 3.68 | 0.00034 |
NFIB | NM_005596 | nuclear factor I/B | 3.46 | 0.00010 |
INHBB | NM_002193 | inhibin, beta B (activin AB beta polypeptide) | 3.32 | 0.00059 |
TCF7L1 | NM_031283 | transcription factor 7-like 1 (T-cell specific, HMG-box) | 3.14 | 0.00073 |
EPC2 | NM_053001 | enhancer of polycomb homolog 2 (Drosophila) | 2.95 | 0.00090 |
GATA1 | NM_002049 | GATA binding protein 1 (globin transcription factor 1) | 2.57 | 0.00082 |
KITLG | NM_000899 | KIT ligand | 2.50 | 0.00052 |
ERRFI1 | NM_018948 | ERBB receptor feedback inhibitor 1 | 2.45 | 0.00074 |
CADM1 | NM_014333 | cell adhesion molecule 1 | −22.84 | 0.00077 |
TREM2 | NM_018965 | triggering receptor expressed on myeloid cells 2 | −9.90 | 0.00017 |
ALOX5AP | NM_001629 | arachidonate 5-lipoxygenase-activating protein | −9.32 | 0.00017 |
PLA2G7 | NM_005084 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | −7.66 | 0.00007 |
CD74 | NM_004355 | CD74 molecule, major histocompatibility complex, class II invariant chain | −7.28 | 0.00006 |
MADCAM1 | NM_130760 | mucosal vascular addressin cell adhesion molecule 1 | −6.53 | 0.00004 |
CD14 | NM_130760 | CD14 molecule | −5.94 | 0.00038 |
CTSA | NM_000308 | cathepsin A | −3.29 | 0.00068 |
CTSC | NM_001814 | cathepsin C | −2.97 | 0.00085 |