Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

BMC Cancer

Table 1 Clinico-pathologic parameters and correlation with CD68⁺ macrophage tumor infiltration

Tumors	No.	%		CD68⁺ intra-tumoral TAMs
n = 491				Evaluation 1 Evaluation 2
Histotype
AC	228	46.4
SCC	244	49.7
ASQ	19	3.9
pT
T1	100	20.4	SC	0.000	0.008
T2	268	54.6	p	0.993	0.859
T3	74	15.1
T4
pN
N0	257	52.3	SC	-0.022	-0.072
N1	147	29.9	p	0.706	0.116
N2	77	15.7
N3	10	2.0
pM
M0	448	91.2	SC	-0.117	-0.006
M1	43	8.8	p	0.082	0.161
Grade
G1	28	5.7	SC	0.227	0.025
G2	253	51.1	p	≤ 0.001*	≤ 0.001 *
G3	210	42.8
Size
≤ 3.7 cm	246	50.1	SC	0.072	0.080
> 3.7 cm	245	49.9	p	0.114	0.079

*for G1 and G2 vs. G3
Abbreviations: AC Adenocarcinoma, SCC Squamous Cell Carcinoma, ASQ Adeno-squamous Carcinoma
p-values and Spearman correlation values (SC) are indicated. Statistical analysis was done with SPSS 16.0

ISSN: 1471-2407