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Table 8 The discordant rates of KRAS mutation status between primary tumors and respective metastatic sites a,b

From: Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer

  Concordant cases, N (%) Discordant cases, N (%) Total N P-value
Liver 42 (89.4) 5 (10.6) 47 -
Lung 25 (67.6) 12 (32.4) 37 0.014
Peritoneum 26 (86.7) 4 (13.3) 30 0.730
Distant lymph nodes 15 (88.2) 2 (11.8) 17 1.000
Ovary 9 (81.8) 2 (18.2) 11 0.607
  1. a The discordant rates of KRAS mutation status between primary tumors and respective metastatic sites (lung, peritoneum, distant lymph nodes and ovary) were compared with the discordant rate of KRAS status between primary tumor and hepatic metastatic sites (10.6%) using the Pearson’s chi square or Fisher’s exact tests.
  2. b The KRAS discordant rate of lung metastasis (32.4%; 12/37) was also significantly higher when compared with the discordant rate of combining all other metastatic organs [12.3%; 13/106 (P = 0.005)].