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Table 6 Analysis of metastatic patterns among patients with single organ-only metastasis (N = 113) a

From: Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer

Initial metastatic or recurred site WT KRAS MT KRAS Total Na P-value
  N (%) N (%)   
Liver     < 0.001
 Yes 34 (65.4) 17 (27.9) 51  
 No 18 (34.6) 44 (72.1) 62  
Lung     < 0.001
 Yes 6 (11.5) 25 (41.0) 31  
 No 46 (88.5) 36 (59.0) 82  
Distant lymph nodes     0.411
 Yes 4 (7.7) 2 (3.3) 6  
 No 48 (92.3) 59 (96.7) 107  
Peritoneumb     0.062
 Yes 7 (13.5) 17 (27.9) 24  
 No 45 (86.5) 44 (72.1) 89  
  1. a The association between initial metastatic or recurred sites and KRAS status was analyzed in patients with metastasis confined to a single organ at the time of diagnosis of MRCRC (N = 113; 30 patients with initial systemic metastasis involving ≥ 2 organs simultaneously at the time of diagnosis of MRCRC were excluded).
  2. b Of 24 patients, cases with simultaneous peritoneal and ovarian metastases (N = 6) were included; there were no cases with ovarian metastasis alone without peritoneal metastasis in our study. When patients with peritoneal metastasis only without Krukenberg tumor (N = 107) were separately analyzed, the result was not different [WT KRAS 10.0% (5/50) vs. MT KRAS 22.8% (13/57); P = 0.077].
  3. Abbreviations: WT, wild-type; MT, mutant-type; MRCRC, metastatic or recurrent colorectal cancer.