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Table 5 Association between initial metastatic or recurred sites and KRAS mutational status (N = 143) a

From: Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer

Initial metastatic or recurred site WT KRAS MT KRAS Total N P-value
  N (%) N (%)   
Liver     < 0.001
 Yes 48 (70.6) 28 (37.3) 76  
 No 20 (29.4) 47 (62.7) 67  
Lung     0.003
 Yes 15 (22.1) 34 (45.3) 49  
 No 53 (77.9) 41 (54.7) 94  
Distant lymph nodes     0.025
 Yes 13 (19.1) 5 (6.7) 18  
 No 55 (80.9) 70 (93.3) 125  
Peritoneum     0.451
 Yes 17 (25.0) 23 (30.7) 40  
 No 51 (75.0) 52 (69.3) 103  
Ovaryb     0.885
 Yes 5 (7.4) 6 (8.0) 11  
 No 63 (92.6) 69 (92.0) 132  
  1. a Initial metastatic or recurred sites were defined as the organs involved by distant metastasis at the time point of diagnosis of stage IV cancer (initial stage IV disease) or recurrence with distant metastasis (recurred cases from initial stage I-III disease). In these analyses, all enrolled cases (N = 143) were included.
  2. bAll cases who had Krukenberg tumors as the initial metastatic or recurred sites had peritoneal metastasis simultaneously. There were no cases with ovarian metastasis alone without peritoneal metastasis in our study.
  3. Abbreviations: WT, wild-type; MT, mutant-type.