Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer

Table 4 Analyses of KRAS discordance patterns in KRAS discordant cases (N = 25)

Characteristic	WT (P) → MT (M)	MT (P) → WT (M)	Total N	P-value
	N (%)	N (%)
Clinical situations for the development of systemic metastasis				0.411
Stage IV at the time of initial diagnosis	7 (43.8)	9 (56.3)	16
Recurred after curative resection	6 (66.7)	3 (33.3)	9
Analyzed metastatic sites				0.377
Liver	1 (20.0)	4 (80.0)	5
Lung^a	6 (50.0)	6 (50.0)	12
Distant lymph nodes	1 (50.0)	1 (50.0)	2
Peritoneum	3 (75.0)	1 (25.0)	4
Ovary	2 (100.0)	0 (0.0)	2

Abbreviations: WT, wild-type; P, primary tumors; MT, mutant-type; M, paired metastatic sites.
^a There was no statistically significant difference in the KRAS discordance pattern between the lung and other paired metastatic organs (P = 1.000).

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