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Table 1 Patient characteristics (N = 143) and the association between KRAS mutational status and clinicopathologic parameters

From: Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer

Characteristic No. of patients
  All KRAS WT KRAS MT P-value
  N N (%) N (%)  
Gender     0.897
 Male 77 37 (54.4) 40 (53.3)  
 Female 66 31 (45.6) 35 (46.7)  
Age     0.303
 < 65 years 97 49 (72.1) 48 (64.0)  
 ≥ 65 years 46 19 (27.9) 27 (36.0)  
Clinical situations for the development of systemic metastasis     0.010
 Stage IV at the time of initial diagnosis 101 55 (80.9) 46 (61.3)  
 Recurred after curative resection 42 13 (19.1) 29 (38.7)  
Primary site     0.802
 Colon 108 52 (76.5) 56 (74.7)  
 Rectum 35 16 (23.5) 19 (25.3)  
Histology and grade     0.819
 ADC, well differentiated 5 2 (2.9) 3 (4.0)  
 ADC, moderately differentiated 118 56 (82.4) 62 (82.7)  
 ADC, poorly differentiated 12 7 (10.3) 5 (6.7)  
 ADC, mucinous 8 3 (4.4) 5 (6.7)  
Gross morphology of primary tumor     0.421
 Ulceroinfiltrative 66 33 (48.5) 33 (44.0)  
 Ulcerofungating 63 28 (41.2) 35 (46.7)  
 Polypoid 7 2 (2.9) 5 (6.7)  
 Unknown 7 5 (7.4) 2 (2.7)  
Obstruction of primary tumor     0.371
 Yes 43 18 (26.5) 25 (33.3)  
 No 100 50 (73.5) 50 (66.7)  
Perforation of primary tumor     1.000
 Yes 10 5 (7.4) 5 (6.7)  
 No 133 63 (92.6) 70 (93.3)  
Microsatellite instability     0.343
 Stable 121 58 (85.3) 63 (84.0)  
 Low frequency 11 3 (4.4) 8 (10.7)  
 High frequency 2 1 (1.5) 1 (1.3)  
 Unknown 9 6 (8.8) 3 (4.0)  
  1. Abbreviations: WT, wild-type; MT, mutant-type; ADC, adenocarcinoma.