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Table 7 Multivariate analysis for overall survival (OS) in Subgroup A and Subgroup C

From: Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)

 

OS

 

Parameter

SE

HR

95% CI

Wald’s p

Subgroup A(1st line, chemo-naïve)

Gender

     

 Women vs. Men

−0.586

0.315

0.557

0.300-1.033

0.063

Histology

     

 Other vs. adenoCa

0.378

0.201

1.459

0.984-2.164

0.060

Treatment

     

 Platinum vs. taxanes

−0.306

0.272

0.736

0.432-1.255

0.260

 tax/plat vs. taxanes

−1.098

0.233

0.334

0.211-0.527

<0.0001

 Other vs. taxanes

−0.086

0.417

0.918

0.405-2.079

0.837

Subgroup C (Chemo-naïve, 1st line and non-relapsed adjuvant)

Gender

     

 Women vs. Men

−0.552

0.311

0.576

0.313-1.058

0.075

Stage

     

 IIIb-IV vs. I-IIIa

1.224

0.267

3.399

1.136-2.576

<0.0001

Histology

     

 Other vs. adenoCa

0.549

0.203

1.731

1.136-2.576

0.007

Treatment

     

 Platinum vs. taxanes

−0.174

0.271

0.840

0.494-1.430

0.522

 tax/plat vs. taxanes

−0.647

0.247

0.524

0.323-0.849

0.009

 other vs. taxanes

0.042

0.415

1.043

0.463-2.350

0.920