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Table 7 Multivariate analysis for overall survival (OS) in Subgroup A and Subgroup C

From: Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)

  OS
  Parameter SE HR 95% CI Wald’s p
Subgroup A(1st line, chemo-naïve)
Gender      
 Women vs. Men −0.586 0.315 0.557 0.300-1.033 0.063
Histology      
 Other vs. adenoCa 0.378 0.201 1.459 0.984-2.164 0.060
Treatment      
 Platinum vs. taxanes −0.306 0.272 0.736 0.432-1.255 0.260
 tax/plat vs. taxanes −1.098 0.233 0.334 0.211-0.527 <0.0001
 Other vs. taxanes −0.086 0.417 0.918 0.405-2.079 0.837
Subgroup C (Chemo-naïve, 1st line and non-relapsed adjuvant)
Gender      
 Women vs. Men −0.552 0.311 0.576 0.313-1.058 0.075
Stage      
 IIIb-IV vs. I-IIIa 1.224 0.267 3.399 1.136-2.576 <0.0001
Histology      
 Other vs. adenoCa 0.549 0.203 1.731 1.136-2.576 0.007
Treatment      
 Platinum vs. taxanes −0.174 0.271 0.840 0.494-1.430 0.522
 tax/plat vs. taxanes −0.647 0.247 0.524 0.323-0.849 0.009
 other vs. taxanes 0.042 0.415 1.043 0.463-2.350 0.920