Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)

Table 1 Association of B, E, R, T mRNA expression with clinicopathologic parameters of NSCLC

		BRCA1		ERCC1		RRM1		TYMS
	N	median	range	median	range	median	range	median	range
All tumors#		36.88	23.13−14.34	39.30	23.13−14.95	38.57	19.54−14.02	36.76	23.85−40.25
Gender
Men	222	37.09	23.13−40.34	39.30	23.13−14.95	38.57	19.54−14.02	36.76	23.85−40.25
Women	54	36.24	32.95−39.22	38.22	35.81−40.87	37.95	30.60−41.94	36.51	30.99−39.88
P		0.0053		0.0169		0.3615		0.4391
Smoking
Never	29	36.16	27.80−39.06	39.01	27.58−40.45	38.19	19.54−41.23	36.45	32.33−39.07
Former	26	36.21	32.13−39.68	38.84	23.13−40.67	38.16	23.13−43.02	36.00	32.63−40.25
Current	150	37.08	32.34−40.34	39.36	32.27−41.95	38.84	23.34−43.02	36.00	32.63−40.25
P		0.0017		0.2694		0.1541		0.0146
Histology
Adeno	159	36.38	23.13−39.24	38.83	23.13−41.95	38.04	20.76−41.60	36.12	30.70−39.36
SCC	70	37.90	33.94−40.34	93.76	35.40−41.23	39.80	19.83−43.02	37.50	23.85−40.20
LCC/undiff	47	37.33	30.15−39.98	39.11	29.58−40.89	38.33	19.54−42.38	37.21	31.59−40.25
P		<0.0001		<0.0001		<0.0001		<0.0001
Stage
I & II	53	37.16	23.13−40.34	39.16	23.13−41.13	38.52	22.49−43.02	36.79	23.85−40.20
IIIA	34	37.60	34.74−39.96	39.70	36.22−41.23	39.30	30.60−42.26	37.48	31.89−40.20
IIIB & IV	137	36.61	27.80−39.68	39.26	27.58−41.95	38.54	19.54−42.38	36.57	30.99−40.25
P		0.0064		0.5083		0.2249		0.1006

Notes to Table 1: Medians and range represent RQ values that are expressed as (40-dCT); p = Mann Whitney Asymptotic significance for gender and Kruskal-Wallis for the rest; # = the number of tumors with informative BRCA1 RQ values was 274, and for all other genes 276; undiff = undifferentiated; SCC = squamous cell, and LCC = large cell carcinoma; stage = stage at initial diagnosis.

ISSN: 1471-2407